{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T04:16:40Z","timestamp":1728101800758},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gmj"],"abstract":"<jats:p>Objectives: Previous studies suggest that patients\u2019 thyroid status might directly impact the course of Coronavirus disease 2019 (COVID-19). The objective of the study was to determine the clinical profile of COVID-19 patients with hypothyroidism and compare it with that of COVID-19 patients without hypothyroidism.Design: Retrospective observational studySetting: The study was conducted in a tertiary healthcare centre in Tamil Nadu between May and June 2021.Participants: The study included 117 patients admitted with hypothyroidism and COVID-19 as well as 117 age and Gender matched COVID-19 patients without hypothyroidism.Main outcome measures: Data regarding the demography, comorbidities, presenting symptoms, method of diagnosis of COVID-19, computed tomography (CT) severity score, Interleukin 6 (IL-6), D-dimer, oxygen requirement, number of days in hospital and outcome were collected for both groups. Data analysis was conducted, and p&lt;0.05 was considered statistically significant.Results: The study comprised 234 patients over two months, from May to June 2021. Distribution of presenting symptoms showed that the hypothyroidism group presented with a higher incidence of fever (66.67%), loose stool (18.80%) and myalgia (7.69%). Results show that RTPCR+, O2 Requirement, death, D-dimer, IL-6, number of days admitted as well as CT-severity did not show any statistically significant differences (p&gt;0.05) between both groups. The outcomes also showed that both groups reported four mortalities.Conclusions: The results of the study help conclude that the hypothyroidism status of a COVID-19 patient is not associated with higher severity of clinical symptoms, deranged laboratory values as well as mortality.<\/jats:p>","DOI":"10.4314\/gmj.v58i3.3","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T14:07:43Z","timestamp":1728050863000},"page":"192-197","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without hypothyroidism"],"prefix":"10.4314","volume":"58","author":[{"given":"Sindhu","family":"Malini B","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoganathan","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement","family":"Jenil Dhas C P","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navinkumar","family":"B K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujith","family":"Kumar S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2024,9,30]]},"container-title":["Ghana Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/279318\/263487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/279318\/263487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T14:07:48Z","timestamp":1728050868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/view\/279318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9,30]]}},"URL":"https:\/\/doi.org\/10.4314\/gmj.v58i3.3","relation":{},"ISSN":["0016-9560"],"issn-type":[{"value":"0016-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}