{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:13:41Z","timestamp":1766391221515,"version":"3.41.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gmj"],"abstract":"<jats:p>Objectives: This study determined the profile of spontaneous bacterial peritonitis (SBP) and its variants in patients with decompensated liver cirrhosis and hepatocellular carcinoma (HCC).Design: A descriptive cross-sectional studySetting: The study was conducted in a tertiary hospital.Participants: Patients with decompensated liver cirrhosis and HCC above 18 years.Interventions: Ascitic fluid (AF) samples were taken for cell count and culture using a BACTEC culture bottle. Sensitivity patterns and ascitic fluid total protein and albumin levels were also assessed.Main outcome measures: Clinical profile of SBP, organisms isolated from the ascitic fluid and sensitivity of isolated organisms to antibiotics.Results: One hundred and six (106) participants were recruited. Seventy (66%) had liver cirrhosis, and 36 (34%) had HCC. The mean age was 50.08\u00b112.66years. Eighty-nine (84%) were males and 17(16%) were females. The overall prevalence of SBP was 29.2% (n = 31). Classical SBP was 5(4.7%), CNNA 20(18.9%) and monobacterial ascites 6(5.7%). The Gram-positive isolates were Staphylococcus aureus 5(45.5%) \u2013 [2(18.2%) MRSA, 3(27.3%) MSSA] while the Gram-negative organisms were E. coli 3(27.3%), Acinectobacter 2(18.2%) and Bulkholderia cepacia 1 (9.1%). Gram-negative bacteria showed absolute resistance to cephalosporins but were all susceptible to meropenem. Gram-positive bacteria showed 100% susceptibility to linezolid, vancomycin and daptomycin. Gram-positive bacteria also showed low resistance to fluoroquinolones (20%). Multi-drug resistance pattern was reported for MRSA, Acinetobacter baumannii and Bulkholderia cepacia.Conclusion: SBP is a common complication in patients with decompensated CLD. Guided antibiotic treatment should be encouraged, particularly in light of the emergence of multidrug resistance patterns.<\/jats:p>","DOI":"10.4314\/gmj.v59i2.2","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T11:26:07Z","timestamp":1750764367000},"page":"52-59","source":"Crossref","is-referenced-by-count":1,"title":["Characterising spontaneous bacterial peritonitis in liver cirrhosis and hepatocellular carcinoma in southwestern Nigeria."],"prefix":"10.4314","volume":"59","author":[{"given":"Abosede","family":"G. Adeyeye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeyemi","family":"T. Adeyemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"O. Adeyeye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitope","family":"O. Ojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusegun","family":"Adekanle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"C. Anuforo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"O. Aboderin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"A. Ndububa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2025,6,21]]},"container-title":["Ghana Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/298323\/280514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/download\/298323\/280514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T12:20:03Z","timestamp":1751458803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/gmj\/article\/view\/298323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,21]]}},"URL":"https:\/\/doi.org\/10.4314\/gmj.v59i2.2","relation":{},"ISSN":["0016-9560"],"issn-type":[{"type":"print","value":"0016-9560"}],"subject":[],"published":{"date-parts":[[2025,6,21]]}}}