{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:07:46Z","timestamp":1790633266034,"version":"4.1.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mal. Med. J"],"abstract":"<jats:p>Background Toxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to inform clinicians about the significance of maternal toxoplasmosis in antenatal care.AimThis study aimed to determine the seroprevalence of Toxoplasma gondii infection, associated CD4+ T-cell profile and sociodemographic risk factors among pregnant women with or without HIV infection attending the University of Abuja Teaching Hospital, Abuja, Nigeria. MethodsThis hospital-based cross-sectional study involved blood samples collected from 160 HIV-infected and 160 HIV-seronegative pregnant women. These samples were analysed for anti-T. gondii (IgG and IgM) and CD4+ T-cell count using ELISA and flow cytometry, respectively. Sociodemographic variables of participants were collected using structured questionnaires. ResultsThe overall seroprevalence of anti-T. gondii IgG and IgM was 28.8% and 3.8%, respectively. The seroprevalence of anti-T. gondii IgG and IgM was 29.4% and 4.4%, respectively, among HIV-seropositive pregnant women and 28.1% and 3.1%, respectively, among HIV-seronegative women. There was no significant association between the seroprevalence of anti-T. gondii-IgG and anti-T. gondii-IgM with age, gestational age, education level, parity or place of residence of HIV-infected pregnant women (P &gt; 0.05). However, there was significant association between the seroprevalence of anti-T. gondii-IgG (P = 0.03) and anti-T. gondii-IgM (P = 0.01) with education level. CD4+ T-cell count varied significantly between HIV-infected and HIV-uninfected pregnant women (P = 0.035). Conclusion In this study, the seroprevalence of anti-T. gondii IgG and IgM did not differ in HIV-seropositive or HIV-seronegative pregnant women. However, women with primary T. gondii and HIV coinfection had lower CD4+ T-cell count than those with toxoplasmosis monoinfection. <\/jats:p>","DOI":"10.4314\/mmj.v32i3.9","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T13:47:15Z","timestamp":1617889635000},"page":"169-176","source":"Crossref","is-referenced-by-count":10,"title":["Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria"],"prefix":"10.4314","volume":"32","author":[{"given":"Maryam","family":"Zakari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2895","published-online":{"date-parts":[[2020,10,30]]},"container-title":["Malawi Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/mmj\/article\/download\/201128\/189649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/mmj\/article\/download\/201128\/189649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T13:47:20Z","timestamp":1617889640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/mmj\/article\/view\/201128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,10,30]]}},"URL":"https:\/\/doi.org\/10.4314\/mmj.v32i3.9","relation":{},"ISSN":["1995-7262","1995-7262"],"issn-type":[{"value":"1995-7262","type":"electronic"},{"value":"1995-7262","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,30]]}}}