{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:46:53Z","timestamp":1762955213652,"version":"3.45.0"},"reference-count":0,"publisher":"African Journals Online (AJOL)","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rwanda J Med Health Sci"],"abstract":"<jats:p>Background Ascertaining the stage of chronic hepatitis-B infection (CHBI) remains one of the major predicaments to effective therapeutic decision. There is pressing need to forestall dearth of such reliable biomarker(s). Despite the promising tendency of alpha-fetoprotein (AFP), it has not been assessed in staging CHBI.ObjectiveThis study was to determine the prognosis of serum AFP as a biomarker for staging CHBI. MethodsParticipants were grouped into three based on their hepatitis-B envelope antigen (HBeAg) status and alanine aminotransferase (ALT) level. By denoting HbeAg(+) as (EP), HbeAg(-) as (EN), elevated ALT as (H) and normal ALT as (I), the stages were EPH, ENH and ENI. AFP was assayed, One-way ANOVA, Multivariate linear regression and area under curve were adopted for the analysis. ResultsAFP was significantly elevated, (P &lt; 0.05) in EPH, which equally has the highest prevalence of elevated AFP (64.7%). After adjusting for confounding factors, odds ratio was 1.438 (95% CI, 0.62\u20131.948), while area under the curve for predicting EPH was (0.828, 95% CI, 0.778 \u20130.895).ConclusionsThe finding of elevated AFP in CHBI is an independent prognostic marker of EPH. It is often associated with necroinflammation; thus, it is a reliable indicator for treatment initiation.Rwanda J Med Health Sci 2023;6(3):355-366<\/jats:p>","DOI":"10.4314\/rjmhs.v6i3.9","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T08:48:45Z","timestamp":1702457325000},"page":"355-366","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of Alpha-Fetoprotein in Staging of Chronic Hepatitis B Infection"],"prefix":"10.4314","volume":"6","author":[{"given":"Olubunmi","family":"Gloria Ayelagbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Eleha","family":"Suleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olutoyin Catherine","family":"Adekunle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adebayo Lawrence","family":"Adedeji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2895","published-online":{"date-parts":[[2023,11,30]]},"container-title":["Rwanda Journal of Medicine and Health Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.ajol.info\/index.php\/rjmhs\/article\/download\/260891\/270913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajol.info\/index.php\/rjmhs\/article\/download\/260891\/270913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:38:37Z","timestamp":1762954717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajol.info\/index.php\/rjmhs\/article\/view\/260891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.4314\/rjmhs.v6i3.9","relation":{},"ISSN":["2616-9827","2616-9819"],"issn-type":[{"type":"electronic","value":"2616-9827"},{"type":"print","value":"2616-9819"}],"subject":[],"published":{"date-parts":[[2023,11,30]]}}}