{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:08:43Z","timestamp":1780628923252,"version":"3.54.1"},"reference-count":28,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Radiol"],"abstract":"<jats:p>Acromegaly, characterized by persistent hypersecretion of growth hormone (GH), is most often caused by a pituitary neuroendocrine tumor (PitNET), though, less often, ectopic GH or GH-releasing hormone secretion from various neoplasms outside the pituitary gland could cause it. Nearly 70% of somatotroph PitNETs are macroadenomas at diagnosis. Transsphenoidal surgery, the most effective treatment modality for acromegaly, could achieve remission in 73%. However, the remission rates could reach 87% if surgery is followed by medical therapy. Due to variable therapeutic responses to surgical and medical therapy, pre-treatment awareness regarding the best therapeutic modality based on clinical, biochemical, radiological, histopathological and genetic parameters would help in accurate pretreatment decision-making. Earlier studies have identified poor prognosis markers like tumor size, tumor invasion, T2-weighted hyperintensity, granulation, and pretreatment GH and\/or insulin-like growth factor 1 levels. In a recent study, published by Alvarez et al  identified that preoperative PitNET volume is a good predictor of control of acromegaly following surgical treatment and the likelihood of requiring more aggressive additional therapies after surgery. They found that PitNET volume exceeding 3697 mm\u00b3 was associated with poorer disease control in patients with somatotroph PitNETs.<\/jats:p>","DOI":"10.4329\/wjr.v17.i6.106438","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:27:36Z","timestamp":1750901256000},"source":"Crossref","is-referenced-by-count":2,"title":["Factors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence?"],"prefix":"10.4329","volume":"17","author":[{"given":"Cornelius J","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Bashar M","family":"Kamrul-Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Pappachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000541671"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00244-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071377"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-023-01360-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0324"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab901"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-024-01432-w"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0788-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2019.06.04"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000001249"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0254"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0766-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0356"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14946"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0840"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad378"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-024-09928-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3171\/2020.3.FOCUS2080"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02121-6"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1055\/a-2081-1427"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2022.101502"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.11.007"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3171\/2024.7.JNS24373"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa040"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0038"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0681-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0835-5"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v17.i3.100168"}],"container-title":["World Journal of Radiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1949-8470\/full\/v17\/i6\/106438.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1949-8470\/full\/v17\/i6\/106438.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:27:47Z","timestamp":1750901267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1949-8470\/full\/v17\/i6\/106438.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":28,"journal-issue":{"issue":"6"},"alternative-id":["106438"],"URL":"https:\/\/doi.org\/10.4329\/wjr.v17.i6.106438","relation":{},"ISSN":["1949-8470"],"issn-type":[{"value":"1949-8470","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,28]]}}}