{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T02:27:38Z","timestamp":1775528858790,"version":"3.50.1"},"reference-count":21,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Cardiol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Coronary artery disease (CAD) is a leading cause of global cardiovascular mortality. Refractory angina pectoris, a manifestation of CAD, requires effective drug treatments. Pericarpium Trichosanthis injection, a traditional Chinese medicine, improves cardiovascular symptoms, while nicorandil alleviates spasms and angina. Both have potential in treating CAD.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the therapeutic effects of combining Pericarpium Trichosanthis injection and nicorandil in elderly patients suffering from refractory angina caused by coronary heart disease.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A retrospective analysis was conducted on the data of 130 patients diagnosed with refractory coronary heart disease. Based on the different treatment regimens administered during hospitalization, the patients were divided into a control group (58 cases) and a study group (72 cases). The control group received conventional treatment, which included aspirin, statins, and nitrate vasodilators. In addition to the conventional medication, the study group received a combination treatment of Pericarpium Trichosanthis injection and nicorandil.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>After treatment, the study group showed significantly higher left ventricular ejection fraction and cardiac output, and lower brain natriuretic peptide and C-reactive protein levels compared to the control group. The study group also exhibited improvements in angina, quality of life, exercise endurance, and lipid profiles. Multivariate logistic regression analysis revealed a relationship of lipid levels and heart function with the combined treatment. Some patients in the study group experienced headaches during treatment, but no significant adverse reactions were observed. Follow-up showed that the treatment was well-tolerated, with no drug-related adverse reactions detected.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Combination of Pericarpium Trichosanthis injection and nicorandil is more effective than conventional treatment in improving symptoms and heart function in elderly patients with refractory angina pectoris.<\/jats:p>","DOI":"10.4330\/wjc.v15.i12.633","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T06:35:15Z","timestamp":1703486115000},"page":"633-641","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and prognostic impact of Pericarpium Trichosanthis injection combined with nicorandil for intractable angina pectoris in elderly patients: A retrospective study"],"prefix":"10.4330","volume":"15","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo-Wei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Yu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-Bi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101936"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suad102"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.113950"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(17)30020-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2023.2209441"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.12037\/YXQY.2018.06-01"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-9572.2015.02.029"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.0957"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00477-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.025"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.054"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117096"},{"key":"B15","unstructured":"Han G. 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