{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:23:42Z","timestamp":1776371022215,"version":"3.51.2"},"reference-count":20,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Cardiol"],"abstract":"BACKGROUND<\/jats:p>\n The utility of D-dimer (DD) as a biomarker for acute aortic dissection (AD) is recognized. Yet, its predictive value for in-hospital mortality remains uncertain and subject to conflicting evidence.<\/jats:p>\n AIM<\/jats:p>\n To conduct a meta-analysis of AD-related in-hospital mortality (ADIM) with elevated DD levels.<\/jats:p>\n METHODS<\/jats:p>\n We searched PubMed, Scopus, Embase, and Google Scholar for AD and ADIM literature through May 2022. Heterogeneity was assessed using I 2 statistics and effect size (hazard or odds ratio) analysis with random-effects models. Sample size, study type, and patients\u2019 mean age were used for subgroup analysis. The significance threshold was P < 0.05.<\/jats:p>\n RESULTS<\/jats:p>\n Thirteen studies (3628 patients) were included in our study. The pooled prevalence of ADIM was 20% (95%CI: 15%-25%). Despite comparable demographic characteristics and comorbidities, elevated DD values were associated with higher ADIM risk (unadjusted effect size: 1.94, 95%CI: 1.34-2.8; adjusted effect size: 1.12, 95%CI: 1.05-1.19, P < 0.01). Studies involving patients with a mean age of < 60 years exhibited an increased mortality risk (effect size: 1.43, 95%CI: 1.23-1.67, P < 0.01), whereas no significant difference was observed in studies with a mean age > 60 years. Prospective and larger sample size studies (n > 250) demonstrated a heightened likelihood of ADIM associated with elevated DD levels (effect size: 2.57, 95%CI: 1.30-5.08, P < 0.01 vs effect size: 1.05, 95%CI: 1.00-1.11, P = 0.05, respectively).<\/jats:p>\n CONCLUSION<\/jats:p>\n Our meta-analysis shows elevated DD increases in-hospital mortality risk in AD patients, highlighting the need for larger, prospective studies to improve risk prediction models.<\/jats:p>","DOI":"10.4330\/wjc.v16.i6.355","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:03:47Z","timestamp":1719234227000},"page":"355-362","source":"Crossref","is-referenced-by-count":2,"title":["Impact of D-dimer on in-hospital mortality following aortic dissection: A systematic review and meta-analysis"],"prefix":"10.4330","volume":"16","author":[{"given":"Sashwath","family":"Srikanth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabnam","family":"Abrishami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Mahadevaiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeetha","family":"Nathaniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramanian","family":"Gnanaguruparan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupak","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031264"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009144"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/2048872615594500"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1532\/hsf.3417"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01932-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.067"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.01.41"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.11.59"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4063"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/02676591211029762"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-020-1066-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304158"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/0267659120961937"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-462"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.821928"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03098-x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12665"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2135"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000013"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.024"}],"container-title":["World Journal of Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v16\/i6\/355.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v16\/i6\/355.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:24:01Z","timestamp":1719307441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v16\/i6\/355.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":20,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4330\/wjc.v16.i6.355","relation":{},"ISSN":["1949-8462"],"issn-type":[{"value":"1949-8462","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}