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This review synthesizes recent research on the biological functions, regulatory mechanisms, and targeted therapies related to the ASMase\/Cer pathway in metabolic conditions, including obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. The effects of the ASMase\/Cer pathway on metabolic disease-related indicators, such as glycolipid metabolism, insulin resistance, inflammation, and mitochondrial homeostasis are elucidated. Moreover, this article discusses the therapeutic strategies using ASMase\/Cer inhibitors for inverse prevention and treatment of these metabolic diseases in light of the possible efficacy of blockade of the ASMase\/Cer pathway in arresting the progression of metabolic diseases. These insights offered herein should provide insight into the contribution of the ASMase\/Cer pathway to metabolic diseases and offer tools to develop therapeutic interventions for such pathologies and their severe complications.<\/jats:p>","DOI":"10.4330\/wjc.v17.i2.102308","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:17:13Z","timestamp":1740370633000},"source":"Crossref","is-referenced-by-count":10,"title":["Emerging roles of the acid sphingomyelinase\/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic 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