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In this meta-analysis, LBBP-CRT showed better outcomes than conventional BVP-CRT, including greater QRS duration reduction and left ventricular ejection fraction improvement, along with consistently lower pacing thresholds on follow-up. Additionally, there was a greater reduction in New York Heart Association class and brain natriuretic peptide levels. This study contributes to the growing body of encouraging data on LBBP-CRT from recent years. With ongoing technological advancements and increasing operator expertise, the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.<\/jats:p>","DOI":"10.4330\/wjc.v17.i2.103356","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T09:17:13Z","timestamp":1740388633000},"source":"Crossref","is-referenced-by-count":3,"title":["Left bundle branch pacing cardiac resynchronization therapy <i>vs<\/i> biventricular pacing cardiac resynchronization therapy\u2013time to write a requiem for biventricular pacing-cardiac resynchronization therapy"],"prefix":"10.4330","volume":"17","author":[{"given":"Akshyaya","family":"Pradhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljeet","family":"Saggu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.22.2502"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.074"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.836254"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.06.023"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2020.45"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.048"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.12.022"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.026"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.04.003"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.04.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad043"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2023.15"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.019"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.08.001"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v16.i1.40"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2021.05.019"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14700"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2023.06.011"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1062372"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02413.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308883"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.08.015"}],"container-title":["World Journal of Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i2\/103356.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i2\/103356.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T09:17:57Z","timestamp":1740388677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i2\/103356.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":26,"journal-issue":{"issue":"2"},"alternative-id":["103356"],"URL":"https:\/\/doi.org\/10.4330\/wjc.v17.i2.103356","relation":{},"ISSN":["1949-8462"],"issn-type":[{"value":"1949-8462","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,26]]}}}