{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:25:36Z","timestamp":1789421136791,"version":"build-2803163510"},"reference-count":126,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Cardiol"],"abstract":"<jats:p>Sinus of Valsalva aneurysm (SoVA) is a rare cardiac defect that may be congenital or acquired. It is characterized by abnormal dilatation of the aortic root due to a weakened elastic lamina at the junction of the annulus fibrosus and the aortic media. SoVAs are present in approximately 0.09% of the general population and comprise up to 3.5% of all congenital cardiac defects. It is usually found incidentally on cardiac imaging, with a higher incidence observed in the Western populations and a male-to-female ratio of 4:1. A transthoracic two-dimensional echocardiogram is the initial diagnostic test of choice, which may reveal the characteristic \u201cwindsock deformity\u201d that clinches the diagnosis. Other imaging modalities, such as transesophageal echocardiography and cardiac computed tomography angiography, help provide more extensive details of the aneurysm and its adjacent structures. Management options for ruptured and unruptured SoVA include surgical repair or transcatheter closure, which serves as a game-changing development in treatment. This article aims to provide background information on the epidemiology, pathophysiology, diagnosis, and recent advancements over the past decade in the management of SoVAs.<\/jats:p>","DOI":"10.4330\/wjc.v17.i6.102722","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T22:11:46Z","timestamp":1750371106000},"source":"Crossref","is-referenced-by-count":10,"title":["Diagnosis and treatment options for sinus of Valsalva aneurysms: A narrative review"],"prefix":"10.4330","volume":"17","author":[{"given":"Kevan","family":"English","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.301095719"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009850"},{"key":"B3","unstructured":"Feldman DN, Gade CL, Roman MJ. Ruptured aneurysm of the right sinus of valsalva associated with a ventricular septal defect and an anomalous coronary artery. Tex Heart Inst J 2005; 555-559"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(199902)46:2<210::AID-CCD21>3.0.CO;2-Q"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22359"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(99)01045-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2017.16522"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytab233"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2004.09.008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-2682"},{"key":"B11","doi-asserted-by":"crossref","unstructured":"Sivadasanpillai H, Valaparambil A, Sivasubramonian S, Mahadevan KK, Sasidharan B, Namboodiri N, Thomas T, Jaganmohan T. Percutaneous closure of ruptured sinus of Valsalva aneurysms: intermediate term follow-up results. EuroIntervention 2010; 214-219","DOI":"10.4244\/EIJV6I2A34"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960131204"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(01)00758-8"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13423"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13503"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5046095"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/467935"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2024.02.002"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-023-00420-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.03.022"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197903000-00008"},{"key":"B22","unstructured":"Patra KP, Vanchiere JA, Bocchini JA Jr, Wu AC, Jackson RD, Kiel EA, Mello D. Endocarditis with ruptured sinus of Valsalva aneurysm caused by nonvaccine Streptococcus pneumoniae serotype 21. Tex Heart Inst J 2012; 277-280"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2012.09.008"},{"key":"B24","unstructured":"Del Campo C, Weinberg DM. Sinus of valsalva aneurysm of the non-coronary cusp: repaired in the adult with a Freestyle bioprosthesis. Tex Heart Inst J 2003; 202-204"},{"key":"B25","unstructured":"Miranda D, Peter AA, Osorion J, Ferreira AC. Ruptured aneurysm of the noncoronary sinus of valsalva. Tex Heart Inst J 2005; 586-588"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2018.10.016"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018760656"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd11040100"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytae417"},{"key":"B30","unstructured":"Bhutia E, Kumar D, Shankar B, Das SP, Kishore S. Bicuspid Aortic Valve: An Unusual Cause of Aneurysm of Left Coronary Sinus of Valsalva. Iran J Med Sci 2017; 310-313"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1735924"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.52.4.696"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.08.046"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihjccr.2022.03.006"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/12462.6340"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(63)90142-6"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2020.107209"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2015.04.182"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.753154"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2016.05.033"},{"key":"B41","unstructured":"Tousek P, Krupicka J, L\u00ednkov\u00e1 H, Straka Z, Koldov\u00e1 L, Widimsk\u00fd P. [Huge sinus of Valsalva aneurysm in patient with cystic medial necrosis of the aorta]. Vnitr Lek 2004; 939-942"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.014"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6563"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/s0894-7317(97)70078-6"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14041"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2017.10.005"},{"key":"B47","unstructured":"Schoenhoff FS, Loupatatzis C, Immer FF, Stoupis C, Carrel TP, Eckstein FS. The role of the sinuses of Valsalva in aortic root flow dynamics and aortic root surgery: evaluation by magnetic resonance imaging. J Heart Valve Dis 2009; 380-385"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.case.2022.02.005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(10)61928-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-14-73"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(62)90287-9"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1278289"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-008184"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/172098"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2021.11.007"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15894"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383431"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.10.063"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.case.2021.10.001"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2016.05.002"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12353"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200602000-00019"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-007855"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01383-7"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X221140658"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.12890\/2020_001499"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.197807"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-16-3-e8"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.case.2023.08.005"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.707147"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.17060"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(98)00782-6"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000439"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2021-0403"},{"key":"B75","unstructured":"Mirdamadi A, Mirmohammadsadeghi M, Marashinia F, Nourbakhsh M. Sinus of Valsalva aneurysm: An uncommon presentation. ARYA Atheroscler 2012; 164-166"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.047"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.118240"},{"key":"B78","unstructured":"Topi B, John J, Agarwal A, Nerella N, Shetty V, Sadiq A, Shani J. An uncommon cause of a continuous murmur. Exp Clin Cardiol 2012; 148-149"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.1.105"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173122"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_41_17"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.4103\/jcecho.jcecho_8_18"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-204493"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1177\/2150135111426885"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.191565"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.1990.tb00400.x"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006389116701"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44210"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13655"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2012.02467.x"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3941\/jrcr.v5i8.719"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0649-3"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5589"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-20-630"},{"key":"B95","unstructured":"Fathala A. Depiction of ruptured sinus of Valsalva aneurysms by cardiac computed tomography angiography. Exp Clin Cardiol 2012; 152-154"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2011.e72"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1038-z"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59220"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3570"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90709-i"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(92)90092-c"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytad018"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-006824"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1177\/21501351221109193"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15358"},{"key":"B106","unstructured":"van Son JA, Danielson GK, Schaff HV, Orszulak TA, Edwards WD, Seward JB. Long-term outcome of surgical repair of ruptured sinus of Valsalva aneurysm. Circulation 1994; II20-II29"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.10.044"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181d4739e"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.5114\/kitp.2021.107471"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03282.x"},{"key":"B111","unstructured":"Zikri MA, Stewart RW, Cosgrove DM. Surgical correction for sinus of Valsalva aneurysm. J Cardiovasc Surg (Torino) 1999; 787-791"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs450"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(00)01734-3"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2019-0437"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq323"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.1043"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-022-02873-5"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-14-0106"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-0127-1"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1227761"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2004.01714.x"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12572"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I4A87"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2015.08.001"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2015.06.025"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7036"}],"container-title":["World Journal of Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/102722.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/102722.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T22:11:48Z","timestamp":1750371108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/102722.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":126,"journal-issue":{"issue":"6"},"alternative-id":["102722"],"URL":"https:\/\/doi.org\/10.4330\/wjc.v17.i6.102722","relation":{},"ISSN":["1949-8462"],"issn-type":[{"value":"1949-8462","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}