{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:43:03Z","timestamp":1781595783208,"version":"3.54.5"},"reference-count":28,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Cardiol"],"abstract":"BACKGROUND<\/jats:p>\n The persistent burden of cardiovascular (CV) disease in the United States requires innovative and cost-effective prognostic markers that can be relied upon.<\/jats:p>\n AIM<\/jats:p>\n To provide insights into how adiponectin can predict all-cause mortality and major adverse CV events (MACE) in patients with coronary artery disease (CAD) and to determine the prognostic value of adiponectin in predicting all-cause mortality and MACE in patients with stable CAD.<\/jats:p>\n METHODS<\/jats:p>\n We conducted a systematic search on PubMed, Scopus, and Google Scholar to find relevant studies published through June 2023 evaluating the long-term prognostic role of adiponectin in patients with stable CAD. Using a random effects model with 95%CI, we estimated the odds ratio (OR) while assessing heterogeneity through I\u00b2 statistics. To ensure robustness, we performed a sensitivity analysis using the leave-one-out approach.<\/jats:p>\n RESULTS<\/jats:p>\n After screening, we included five prospective studies involving 3225 patients who were followed up for a median duration of 3.8 years. Within the study population, prevalent risk factors included hypertension, diabetes, hyperlipidemia, and smoking. The commonly prescribed medications were angiotensin-converting enzyme inhibitors, beta blockers, and statins. The combined adjusted OR for all-cause mortality was found to be 2.51 (95%CI: 1.36\u20134.62), showing heterogeneity (I\u00b2 = 65.51%, P = 0.03). On the other hand, the combined adjusted OR for MACE was determined to be 1.04 (95%CI: 1.02\u20131.06) with no significant heterogeneity observed (I\u00b2 = 0%, P = 0.68). Through a sensitivity analysis, it was discovered that none of the studies significantly impacted the overall results of the meta-analysis, thus indicating their robustness.<\/jats:p>\n CONCLUSION<\/jats:p>\n Higher levels of adiponectin were found to be associated with an increased risk of long-term mortality and MACE in patients with CAD, which highlights its potential as a cost-effective marker for risk assessment and guiding treatment strategies. Further research on the role of adiponectin could greatly influence decision-making and resource allocation in CV care.<\/jats:p>","DOI":"10.4330\/wjc.v17.i6.105452","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:11:46Z","timestamp":1750385506000},"source":"Crossref","is-referenced-by-count":3,"title":["Long-term prognostic role of adiponectin in stable coronary artery disease: A meta-analysis of prospective studies"],"prefix":"10.4330","volume":"17","author":[{"given":"Sahas Reddy","family":"Jitta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Vatsavayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenna Reddy","family":"Tera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobana","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saisree Reddy","family":"Adla Jala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha Sanjana","family":"Pasnoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utheja","family":"Dasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Maramreddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Jammula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medha Reddy","family":"Kesani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Tripuraneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-103"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810602040367"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.01.026"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.12.018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S48753"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595918"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618918"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01096-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13619"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.51789\/cmsj.2023.3.e9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1633-p"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071430"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.038"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300079"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20180172"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.04.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52977-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl153"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01395.x"},{"key":"B21","doi-asserted-by":"crossref","unstructured":"Barrios V, G\u00f3mez-Huelgas R, Rodr\u00edguez R, de Pablos-Velasco P. Adiponectina, un factor de riesgo cardiovascular emergente. Estudio REFERENCE [Adiponectin: an emerging cardiovascular risk factor. The REFERENCE Study]. Rev Esp Cardiol 2008; 1159-1167","DOI":"10.1157\/13127847"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1168-3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10586-1"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010108"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2337\/dbi17-0016"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-4572.2008.00048.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1730"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.102.11.1296"}],"container-title":["World Journal of Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/105452.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/105452.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:11:53Z","timestamp":1750385513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1949-8462\/full\/v17\/i6\/105452.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":28,"journal-issue":{"issue":"6"},"alternative-id":["105452"],"URL":"https:\/\/doi.org\/10.4330\/wjc.v17.i6.105452","relation":{},"ISSN":["1949-8462"],"issn-type":[{"value":"1949-8462","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}