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Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration. Virology 2003;308:1-12.","DOI":"10.1016\/S0042-6822(02)00091-0"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Nishimura M, Maeda M, Yasunaga J, Kawakami H, Kaji R, Adachi A, Uchiyama T, Matsuoka M. Influence of cytokine and mannose binding protein gene polymorphisms on human T-cell leukemia virus type I (hTLV-I) provirus load in HTLV-1 asymptomatic carriers. Hum Immunol 2003;64:453-457.","DOI":"10.1016\/S0198-8859(02)00829-7"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Yamada Y, Tomonaga M. The current status of therapy for adult T-cell leukaemia-lymphoma in Japan. Leuk Lymphoma 2003;44:611-618.","DOI":"10.1080\/1042819021000055039"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Edlich RF, Arnette JA, Williams FM. Global epidemic of human T-cell lymphotropic virus type-I (HTLV-1). J Emerg Med 2000;18:109-119.","DOI":"10.1016\/S0736-4679(99)00173-0"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Ohsugi T, Koito A. Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3. J Virol Methods 2007;139:93-96.","DOI":"10.1016\/j.jviromet.2006.08.016"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Matsuoka M. Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene 2003;22:5131-5140.","DOI":"10.1038\/sj.onc.1206551"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Nagai M, Brennan MB, Sakai JA, Mora CA, Jacobson S. CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 2001;98:1858-1861.","DOI":"10.1182\/blood.V98.6.1858"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 2003;115:449-459.","DOI":"10.1016\/S0092-8674(03)00881-X"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Bangham CR. The immune response to HTLV-1. Curr Opin Immunol 2000;12:397-402.","DOI":"10.1016\/S0952-7915(00)00107-2"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Pi\u00f1on JD, Klasse PJ, Jassal SR, Welson S, Weber J, Brighty DW, Sattentau QJ. Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans. J Virol 2003;77:9922-9930.","DOI":"10.1128\/JVI.77.18.9922-9930.2003"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Jones KS, Fugo K, Petrow-Sadowski C, Huang Y, Bertolette DC, Lisinski I, Cushman SW, Jacobson S, Ruscetti FW. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. J Virol 2006;80:8291-8302.","DOI":"10.1128\/JVI.00389-06"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Ceccaldi PE, Delebecque F, Prevost MC, Moris A, Abastado JP, Gessain A, Schwartz O, Ozden S. DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells. J Virol 2006;80:4771-4780.","DOI":"10.1128\/JVI.80.10.4771-4780.2006"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med 2008;14:429-436.","DOI":"10.1038\/nm1745"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Igakura T, Stinchcombe JC, Goon PK, Taylor GP, Weber JN, Griffiths GM, Tanaka Y, Osame M, Bangham CR. Spread of HTLV-1 between lymphocytes by virus-induced polarization of the cytoskeleton. 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Int J Hematol 2007;86:107-112.","DOI":"10.1532\/IJH97.07103"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Gatza ML, Marriott SJ. Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism. J Virol 2006;80:6657-6668.","DOI":"10.1128\/JVI.02270-05"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Alefantis T, Barmak K, Harhaj EW, Grant C, Wigdahl B. Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. J Biol Chem 2003;278:21814-21822.","DOI":"10.1074\/jbc.M211576200"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Smith MR, Greene WC. Identification of HTLV-1 tax trans-activator mutants exhibiting novel transcriptional phenotypes. 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Oncogene 2003;22:5141-5149.","DOI":"10.1038\/sj.onc.1206549"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Harhaj EW, Harhaj NS. Mechanisms of persistent NF-kappaB activation by HTLV-1 tax. IUBMB Life 2005;57:83-91.","DOI":"10.1080\/15216540500078715"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Robek MD, Ratner L. Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J Virol 1999;73:4856-4865.","DOI":"10.1128\/JVI.73.6.4856-4865.1999"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Kitajima I, Shinohara T, Bilakovics J, Brown DA, Xu X, Nerenberg M. Ablation of transplanted HTLV-1 tax-transformed tumors in mice by antisense inhibition of NF-kappa B. Science 1993;259:1523.","DOI":"10.1126\/science.8456277"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Grassmann R, Aboud M, Jeang KT. Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 2005;24:5976-5985.","DOI":"10.1038\/sj.onc.1208978"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Grassmann R, Dengler C, Müller-Fleckenstein I, Fleckenstein B, McGuire K, Dokhelar MC, Sodroski JG, Haseltine WA. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci USA 1989;86:3351-3355.","DOI":"10.1073\/pnas.86.9.3351"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Grossman WJ, Ratner L. Transgenic mouse models for HTLV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13 Suppl 1:S162-S169.","DOI":"10.1097\/00042560-199600001-00025"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 1995;92:1057-1061.","DOI":"10.1073\/pnas.92.4.1057"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y, Ichinohe T, Tsunetsugu-Yokota Y, Katano H, Takahashi H. Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 2006;12:466-472.","DOI":"10.1038\/nm1389"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Kwon H, Ogle L, Benitez B, Bohuslav J, Montano M, Felsher DW, Greene WC. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem 2005;280:35713-35722.","DOI":"10.1074\/jbc.M504848200"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Ng PW, Iha H, Iwanaga Y, Bittner M, Chen Y, Jiang Y, Gooden G, Trent JM, Meltzer P, Jeang KT. Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation. Oncogene 2001;20:4484-4496.","DOI":"10.1038\/sj.onc.1204513"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Inoue J, Seiki M, Taniguchi T, Tsuru S, Yoshida M. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J 1986;5:2883-2888.","DOI":"10.1002\/j.1460-2075.1986.tb04583.x"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Morris JC, Waldmann TA. Advances in interleukin 2 receptor targeted treatment. Ann Rheum Dis 2000;59 Suppl 1:i109-i114.","DOI":"10.1136\/ard.59.suppl_1.i109"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Suzuki T, Kitao S, Matsushime H, Yoshida M. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J 1996;15:1607-1614.","DOI":"10.1002\/j.1460-2075.1996.tb00505.x"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Neuveut C, Low KG, Maldarelli F, Schmitt I, Majone F, Grassmann R, Jeang KT. Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol 1998;18:3620-3632.","DOI":"10.1128\/MCB.18.6.3620"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Haller K, Wu Y, Derow E, Schmitt I, Jeang KT, Grassmann R. Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. Mol Cell Biol 2002;22:3327-3338.","DOI":"10.1128\/MCB.22.10.3327-3338.2002"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A. Protein profile of tax-associated complexes. 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Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-1 Tax protein. Oncogene 2000;19:1448-1456.","DOI":"10.1038\/sj.onc.1203445"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M, Sun SC. Retroviral oncoprotein Tax induces processing of NF-kappaB2\/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 2001;20:6805-6815.","DOI":"10.1093\/emboj\/20.23.6805"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Journo C, Filipe J, About F, Chevalier SA, Afonso PV, Brady JN, Flynn D, Tangy F, Israël A, Vidalain PO. NRP\/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. PLoS Pathog 2009;5:e1000521.","DOI":"10.1371\/journal.ppat.1000521"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Huang J, Ren T, Guan H, Jiang Y, Cheng H. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J Biol Chem 2009;284:6208-6217.","DOI":"10.1074\/jbc.M806390200"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289:2350-2354.","DOI":"10.1126\/science.289.5488.2350"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J 2009;28:513-522.","DOI":"10.1038\/emboj.2008.285"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Shembade N, Harhaj NS, Liebl DJ, Harhaj EW. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J 2007;26:3910-3922.","DOI":"10.1038\/sj.emboj.7601823"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol 2008;9:254-262.","DOI":"10.1038\/ni1563"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004;430:694-699.","DOI":"10.1038\/nature02794"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. J Biol Chem 1997;272:25816-25823.","DOI":"10.1074\/jbc.272.41.25816"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Gachon F, Peleraux A, Thebault S, Dick J, Lemasson I, Devaux C, Mesnard JM. CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter. J Virol 1998;72:8332-8337.","DOI":"10.1128\/JVI.72.10.8332-8337.1998"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J 2008;27:629-641.","DOI":"10.1038\/emboj.2008.5"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol 2007;81:13735-13742.","DOI":"10.1128\/JVI.01790-07"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F. Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol Cell Biol 2005;25:10391-10406.","DOI":"10.1128\/MCB.25.23.10391-10406.2005"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Nasr R, Chiari E, El-Sabban M, Mahieux R, Kfoury Y, Abdulhay M, Yazbeck V, Hermine O, de Thé H, Pique C. Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation. Blood 2006;107:4021-4029.","DOI":"10.1182\/blood-2005-09-3572"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Peloponese JM Jr, Iha H, Yedavalli VR, Miyazato A, Li Y, Haller K, Benkirane M, Jeang KT. Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity. J Virol 2004;78:11686-11695.","DOI":"10.1128\/JVI.78.21.11686-11695.2004"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Bex F, Murphy K, Wattiez R, Burny A, Gaynor RB. Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. J Virol 1999;73:738-745.","DOI":"10.1128\/JVI.73.1.738-745.1999"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Durkin SS, Ward MD, Fryrear KA, Semmes OJ. Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. J Biol Chem 2006;281:31705-31712.","DOI":"10.1074\/jbc.M607011200"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G. HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. Biochem Biophys Res Commun 2008;365:189-194.","DOI":"10.1016\/j.bbrc.2007.10.172"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Kfoury Y, Nasr R, Favre-Bonvin A, El-Sabban M, Renault N, Giron ML, Setterblad N, Hajj HE, Chiari E, Mikati AG. Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome. Oncogene 2008;27:1665-1676.","DOI":"10.1038\/sj.onc.1210804"},{"key":"ref94","doi-asserted-by":"crossref","unstructured":"Chiari E, Lamsoul I, Lodewick J, Chopin C, Bex F, Pique C. Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding. J Virol 2004;78:11823-11832.","DOI":"10.1128\/JVI.78.21.11823-11832.2004"},{"key":"ref95","doi-asserted-by":"crossref","unstructured":"Lodewick J, Lamsoul I, Polania A, Lebrun S, Burny A, Ratner L, Bex F. Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway. Virology 2009;386:68-78.","DOI":"10.1016\/j.virol.2008.12.043"},{"key":"ref96","doi-asserted-by":"crossref","unstructured":"Nyborg JK, Egan D, Sharma N. The HTLV-1 Tax protein: Revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly. 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