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We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART.<\/jats:p><jats:p>Citation: Rance B, Canuel V, Countouris H, Laurent-Puig P, Burgun A. Integrating heterogeneous biomedical data for cancer research: the CARPEM infrastructure.<\/jats:p>","DOI":"10.4338\/aci-2015-09-ra-0125","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T04:35:40Z","timestamp":1462336540000},"page":"260-274","source":"Crossref","is-referenced-by-count":27,"title":["Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure"],"prefix":"10.4338","volume":"07","author":[{"given":"Vincent","family":"Canuel","sequence":"first","affiliation":[]},{"given":"Hector","family":"Countouris","sequence":"first","affiliation":[]},{"given":"Pierre","family":"Laurent-Puig","sequence":"first","affiliation":[]},{"given":"Anita","family":"Burgun","sequence":"first","affiliation":[]},{"given":"Bastien","family":"Rance","sequence":"additional","affiliation":[]}],"member":"194","published-online":{"date-parts":[[2017,12,16]]},"reference":[{"key":"10.4338\/ACI-2015-09-RA-0125-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2013.11.003"},{"key":"10.4338\/ACI-2015-09-RA-0125-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2013.10.003"},{"key":"10.4338\/ACI-2015-09-RA-0125-3","doi-asserted-by":"crossref","unstructured":"Danciu I, Cowan JD, Basford M, Wang X, Saip A, Osgood S, et al. 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