{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:17:45Z","timestamp":1776863865335,"version":"3.51.2"},"reference-count":65,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"crossref","award":["R21HS023963"],"award-info":[{"award-number":["R21HS023963"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Clin Inform"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background: As HIV\/AIDS is considered a chronic disease; quality of life (QoL) has become an important focus for researchers and healthcare providers. Technology-mediated interventions have demonstrated improved clinical effectiveness in outcomes, such as viral suppression, for persons living with HIV\/AIDS (PLWH). However, the evidence to support the impact of these interventions on QoL is lacking.<\/jats:p><jats:p>Objectives: The aim of this paper was to assess the impact of technology-mediated interventions on QoL and to identify the instruments used to measure the QoL of PLWH.<\/jats:p><jats:p>Methods: For this review we followed the PRISMA guidelines. A literature search was conducted in PubMed, CINAHL, Cochrane, and EMBASE databases in April 2016. Inclusion criteria limited articles to those with technology-mediated interventions as compared to usual care; articles with the population defined as HIV-infected patients; and articles with QoL measured as a health outcome in randomized controlled trials. The Cochrane Collaboration Risk of Bias Tool was used to assess study quality.<\/jats:p><jats:p>Results: Of the 1,554 peer-reviewed articles returned in the searches, 10 met the inclusion criteria. This systematic review identified four types of technology-mediated interventions and two types of QoL instruments used to examine the impact of technology-mediated interventions on PLWH. Four studies of technology-mediated interventions resulted in improvement in QoL. Four studies considered QoL as a secondary outcome and resulted in a negative or neutral impact on QoL. Overall, four studies had a low risk of bias, one study had a moderate risk of bias, and the other five studies had a high risk of bias.<\/jats:p><jats:p>Conclusions: The evidence to support the improvement of QoL using technology-mediated interventions is insufficient. This lack of research highlights the need for increased study of QoL as an outcome measure and the need for consistent measures to better understand the role of technology-mediated interventions in improving QoL for PLWH.<\/jats:p><jats:p>Citation: Hwayoung Cho, Sarah Iribarren, Rebecca Schnall. Technology-Mediated Interventions and Quality of Life for Persons Living with HIV\/AIDS: A Systematic Review. Appl Clin Inform 2017; 8: 348\u2013368 https:\/\/doi.org\/10.4338\/ACI-2016-10-R-0175<\/jats:p>","DOI":"10.4338\/aci-2016-10-r-0175","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T02:26:07Z","timestamp":1491963967000},"page":"348-368","source":"Crossref","is-referenced-by-count":26,"title":["Technology-Mediated Interventions and Quality of Life for Persons Living with HIV\/AIDS"],"prefix":"10.4338","volume":"08","author":[{"given":"Hwayoung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Iribarren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Schnall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"10.4338\/ACI-2016-10-R-0175-1","unstructured":"World Health Organization. HIV\/AIDS 2016. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/fs360\/en\/"},{"key":"10.4338\/ACI-2016-10-R-0175-2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624080-00003"},{"key":"10.4338\/ACI-2016-10-R-0175-3","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624080-00003"},{"key":"10.4338\/ACI-2016-10-R-0175-4","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798006667"},{"key":"10.4338\/ACI-2016-10-R-0175-5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135705"},{"key":"10.4338\/ACI-2016-10-R-0175-6","doi-asserted-by":"publisher","DOI":"10.1086\/649216"},{"key":"10.4338\/ACI-2016-10-R-0175-7","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-40"},{"key":"10.4338\/ACI-2016-10-R-0175-8","doi-asserted-by":"crossref","unstructured":"Schnall R, Liu J, Cho H, Hirshfield S, Siegel K, Olender S. A health-related quality of life measure for use in patients with HIV: A validation study. AIDS Patient Care and STDs. 2016.","DOI":"10.1089\/apc.2016.0252"},{"key":"10.4338\/ACI-2016-10-R-0175-9","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-015-0291-7"},{"key":"10.4338\/ACI-2016-10-R-0175-10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq243"},{"key":"10.4338\/ACI-2016-10-R-0175-11","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-014-0984-8"},{"key":"10.4338\/ACI-2016-10-R-0175-12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jana.2013.09.002"},{"key":"10.4338\/ACI-2016-10-R-0175-13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088166"},{"key":"10.4338\/ACI-2016-10-R-0175-14","doi-asserted-by":"crossref","unstructured":"Horvath T, Azman H, Kennedy GE, Rutherford GW. Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection. The Cochrane Database of Systematic Reviews 2012(3): CD009756","DOI":"10.1002\/14651858.CD009756"},{"key":"10.4338\/ACI-2016-10-R-0175-15","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-014-0654-6"},{"key":"10.4338\/ACI-2016-10-R-0175-16","doi-asserted-by":"publisher","DOI":"10.1086\/466526"},{"key":"10.4338\/ACI-2016-10-R-0175-17","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181582d54"},{"key":"10.4338\/ACI-2016-10-R-0175-18","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntr121"},{"key":"10.4338\/ACI-2016-10-R-0175-19","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-015-0292-6"},{"key":"10.4338\/ACI-2016-10-R-0175-20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2012.05.002"},{"key":"10.4338\/ACI-2016-10-R-0175-21","doi-asserted-by":"publisher","DOI":"10.1080\/09540120412331305098"},{"key":"10.4338\/ACI-2016-10-R-0175-22","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00009"},{"key":"10.4338\/ACI-2016-10-R-0175-23","doi-asserted-by":"publisher","DOI":"10.1080\/09540120903334658"},{"key":"10.4338\/ACI-2016-10-R-0175-24","doi-asserted-by":"publisher","DOI":"10.1080\/095401200750003842"},{"key":"10.4338\/ACI-2016-10-R-0175-25","doi-asserted-by":"publisher","DOI":"10.1080\/09540120902732019"},{"key":"10.4338\/ACI-2016-10-R-0175-26","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.4882"},{"key":"10.4338\/ACI-2016-10-R-0175-27","unstructured":"World Health Organization. eHealth 2016. Available from: http:\/\/www.who.int\/topics\/ehealth\/en\/"},{"key":"10.4338\/ACI-2016-10-R-0175-28","unstructured":"HealthIT.gov. What is telehealth? How is telehealth different from telemedicine? 2014. Available from: https:\/\/www.healthit.gov\/providers-professionals\/faqs\/what-telehealth-how-telehealth-different-telemedicine"},{"key":"10.4338\/ACI-2016-10-R-0175-29","unstructured":"World Health Organization. Digital health in TB care and control: Key definitions 2016. Available from: http:\/\/www.who.int\/tb\/areas-of-work\/digital-health\/definitions\/en\/"},{"key":"10.4338\/ACI-2016-10-R-0175-30","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"10.4338\/ACI-2016-10-R-0175-31","unstructured":"Covidence 2016. Available from: http:\/\/www.covidence.org\/"},{"key":"10.4338\/ACI-2016-10-R-0175-32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"10.4338\/ACI-2016-10-R-0175-33","unstructured":"Gustafson DH, Hawkins RP, Boberg EW, Bricker E, Pingree S, Chan CL. The use and impact of a computer-based support system for people living with AIDS and HIV infection. Proceedings \/ the Annual Symposium on Computer Application [sic] in Medical Care Symposium on Computer Applications in Medical Care 1994: 604-608"},{"key":"10.4338\/ACI-2016-10-R-0175-34","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/580974"},{"key":"10.4338\/ACI-2016-10-R-0175-35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014515"},{"key":"10.4338\/ACI-2016-10-R-0175-36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046909"},{"issue":"4","key":"10.4338\/ACI-2016-10-R-0175-37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1071\/SH15064","volume":"12","author":"Millard","year":"2015","journal-title":"Sexual Health"},{"key":"10.4338\/ACI-2016-10-R-0175-38","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0b013e3181df78b9"},{"issue":"1","key":"10.4338\/ACI-2016-10-R-0175-39","first-page":"23","volume":"171","author":"Pyne","year":"2011","journal-title":"Archives of Internal Medicine"},{"key":"10.4338\/ACI-2016-10-R-0175-40","doi-asserted-by":"publisher","DOI":"10.1310\/hct1405-235"},{"key":"10.4338\/ACI-2016-10-R-0175-41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2009.03048.x"},{"key":"10.4338\/ACI-2016-10-R-0175-42","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2006.20.773"},{"key":"10.4338\/ACI-2016-10-R-0175-43","unstructured":"Ware J. The MOS 36-Item Short-Form Health Survey (SF-36). In: Sederer, LI.; Dickey, B., editors. Outcomes Assessment in Clinical Practice. Williams and Wilkins; Baltimore: 1996. p. 61-64"},{"key":"10.4338\/ACI-2016-10-R-0175-44","unstructured":"Rehab Measures: Short Form 12 item (version 2) Health Survey [cited 2015 November 25th]. Available from: http:\/\/www.rehabmeasures.org\/Lists\/RehabMeasures\/DispForm.aspx?ID=1149"},{"key":"10.4338\/ACI-2016-10-R-0175-45","unstructured":"Ware J, Kosinski M, Dewey J. How to Score Version Two of the SF-36\u00ae Health Survey. Lincoln (RI): QualityMetric Incorporated2000"},{"key":"10.4338\/ACI-2016-10-R-0175-46","unstructured":"The M.I.N.I. Medical Outcome Systems2014 [cited 2015 November 25th]. Available from: http:\/\/www.medical-outcomes.com\/index\/mini"},{"key":"10.4338\/ACI-2016-10-R-0175-47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01408.x"},{"key":"10.4338\/ACI-2016-10-R-0175-48","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry 1998; 59(Suppl. 20): 22-33; quiz 4-57"},{"key":"10.4338\/ACI-2016-10-R-0175-49","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020870402019"},{"key":"10.4338\/ACI-2016-10-R-0175-50","unstructured":"WHO. \u201cWHOQOL-HIV BREF, Geneva, Switzerland,\u201d Mental Health: Evidence and Research Department of Mental Health and Substance Dependence 2002. Available from: http:\/\/www.who.int\/mental_health\/media\/en\/613.pdf"},{"key":"10.4338\/ACI-2016-10-R-0175-51","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318245cafe"},{"key":"10.4338\/ACI-2016-10-R-0175-52","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199108000-00011"},{"key":"10.4338\/ACI-2016-10-R-0175-53","unstructured":"Naughton M, Wiklund I. Dimension-specific instruments that may be used across cultures. In: Spilker B. ed. Quality of Life and Pharmacoeconomics in Clinical Trials, Second Edition. Philadelphia: Lippincott-Raven Publishers, 1996: 633-658"},{"key":"10.4338\/ACI-2016-10-R-0175-54","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000064172.46685.82"},{"key":"10.4338\/ACI-2016-10-R-0175-55","unstructured":"Clinical Trials Behavioral and Social Sciences Research [cited 2015 December 2nd]. Available from: http:\/\/www.esourceresearch.org\/eSourceBook\/ClinicalTrials\/4Endpoints\/tabid\/200\/Default.aspx"},{"key":"10.4338\/ACI-2016-10-R-0175-56","unstructured":"Higgins J, Green Se. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from http:\/\/handbook.cochrane.org. 2011"},{"key":"10.4338\/ACI-2016-10-R-0175-57","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61997-6"},{"key":"10.4338\/ACI-2016-10-R-0175-58","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.09.019"},{"key":"10.4338\/ACI-2016-10-R-0175-59","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003155"},{"key":"10.4338\/ACI-2016-10-R-0175-60","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0718-6"},{"key":"10.4338\/ACI-2016-10-R-0175-61","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym087"},{"key":"10.4338\/ACI-2016-10-R-0175-62","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2008.09.040"},{"key":"10.4338\/ACI-2016-10-R-0175-63","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.22.2.140"},{"key":"10.4338\/ACI-2016-10-R-0175-64","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp732"},{"key":"10.4338\/ACI-2016-10-R-0175-65","unstructured":"World Health Organization. International Classification of Functioning, Disability and Health (ICF)"}],"container-title":["Applied Clinical Informatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4338\/ACI-2016-10-R-0175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T19:33:23Z","timestamp":1569008003000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4338\/ACI-2016-10-R-0175"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":65,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2017,12,21]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.4338\/aci-2016-10-r-0175","relation":{},"ISSN":["1869-0327"],"issn-type":[{"value":"1869-0327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}