{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:39:38Z","timestamp":1759991978861,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3940","license":[{"start":{"date-parts":[[2010,9,27]],"date-time":"2010-09-27T00:00:00Z","timestamp":1285545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>\nPRINCIPLES:On the basis of previous  observations we examined the possibility of a favourable effect of proton pump  inhibitors (PPI) on Meniere\u2019s disease (MD). A preliminary step was made by  retrospectively analysing the number of menieric crises in a group of patients  suffering from MD and using PPI for other reasons as compared to a group of  menieric subjects who had never used PPI.\n        METHODS:Between January 2001 and December  2006, 42 patients affected by MD were examined in the tertiary referral centre  at the University Hospital of Bologna, Italy and in the private office of an  ENT specialist in Cassino, Italy. Within the study group, 18 patients had used  PPI for various reasons for at least 12 consecutive months, whilst 24 patients had  never been prescribed them.\n        We  recorded the number of menieric crises reported in the observation period. The  mean follow-up period was 21.9 months. Statistical analysis was performed by  means of the x\n2 test and  significance was defined when p&lt;0.05.\n        RESULTS:Most of MD patients (72%) using PPI suffered less than one episode of  menieric crisis\/year. On the other hand patients who had never used a PPI, experienced  considerably more episodes only 16.7% having less than one crisis per year.  This difference was statistically significant (p&lt;0, 001).\n        CONCLUSIONS: Even taking the limitations of this  retrospective study into account the reported data nevertheless strongly  suggest a possible role for proton pumps in the pathogenesis of MD. This could  lead to interesting developments and contribute to a better definition of MD  and the therapeutic possibilities.<\/jats:p>","DOI":"10.4414\/smw.2010.13104","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13104","source":"Crossref","is-referenced-by-count":1,"title":["Meniere\u2019s  disease and the use of proton pump inhibitors"],"prefix":"10.57187","volume":"140","author":[{"given":"A","family":"Pirodda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GC","family":"Modugno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Manzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Brandolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GG","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2010,9,27]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1197\/1278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1197\/1279","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1197\/1278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:28:11Z","timestamp":1755224891000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,27]]},"references-count":0,"journal-issue":{"issue":"3940","published-online":{"date-parts":[[2010,9,27]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2010.13104","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2010,9,27]]}}}