{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:26:03Z","timestamp":1767597963993,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0304","license":[{"start":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:00:00Z","timestamp":1295222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>PRINCIPLES:  The risk of seizures increases in patients with brain tumours (BT) and brain  vascular malformations (BVM), but not all risk factors are known. We aimed to  identify factors that increase the risk of a first seizure in patients with BT  or BVM.\n        METHODS:  Multicentre case-control study; 102 cases with a first seizure as a presenting  symptom of BT or BVM; 121 hospital controls with BT or BVM, but without  seizures, matched by centre, gender and age.\n        RESULTS:  In the univariate analysis, the risk of first seizure (Odds Ratio, 95%  Confidence Limits) was 6.4 (2.3\u201317.6) for supratentorial lesions, 4.7 (2.4\u20139.3) for cortical involvement, 2.5 (1.0\u20137.7) for  family history of seizures, and 2.1 (1.2\u20134.1) for frontal location. The types  of lesion with higher risk were low grade glioma (4.7; 1.7\u201313.9) and cavernous  malformations (13.2; 2.1\u201358.0). After multivariate analysis, including all the  imaging characteristics and family history, the strongest independent predictors  of first seizure were cortical involvement (OR 4.0; 2.0\u20138.1) and type of lesion  (low grade glioma: 4.0; 1.3\u201312.8; cavernous malformations: 12.6 (1.5\u2013103.5).\n        CONCLUSIONS:  Cortical involvement and type of lesion are the independent risk factors for a  first-ever seizure as a presenting symptom of BT or BVM.<\/jats:p>","DOI":"10.4414\/smw.2011.13155","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13155","source":"Crossref","is-referenced-by-count":6,"title":["Risk  factors for a first epileptic seizure symptomatic of\u00a0brain tumour or brain  vascular malformation"],"prefix":"10.57187","volume":"141","author":[{"given":"MA","family":"Leone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ivashynka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Tonini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bogliun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Montano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ravetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Gambaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Paladin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Beghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2011,1,17]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1240\/1364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1240\/1365","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1240\/1364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:39:46Z","timestamp":1755225586000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,17]]},"references-count":0,"journal-issue":{"issue":"0304","published-online":{"date-parts":[[2011,1,17]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13155","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2011,1,17]]}}}