{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:39:36Z","timestamp":1784194776254,"version":"3.55.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1718","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>In  328 immunocompromised patients, 105 with and 193 without Pneumocystis jiroveci pneumonia (PCP), serum lactate dehydrogenase  (LDH) was analysed retrospectively, taking into consideration the time interval  from the onset of symptoms to the start of specific therapy. 97 of the 105 PCP  patients were negative for human immunodeficiency virus (HIV). Eight were  positive. Of the 193 patients without PCP 134 were HIV-negative and 59 were  HIV-positive. In HIV-negative patients the sensitivity of LDH elevation was 63%  and specificity 43%. In HIV-positive patients sensitivity was 100% and  specificity 47%. The overall accuracy of LDH for the diagnosis of PCP was 52%,  51% in HIV-negative and 58% in HIV-positive patients.\n        Except  for its sensitivity in HIV-positive patients, the value of LDH for the  diagnosis of PCP should not be overestimated.<\/jats:p>","DOI":"10.4414\/smw.2011.13184","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13184","source":"Crossref","is-referenced-by-count":24,"title":["Accuracy  of serum LDH elevation for the diagnosis of\u00a0Pneumocystis  jiroveci pneumonia"],"prefix":"10.57187","volume":"141","author":[{"given":"MN","family":"Vogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Weissgerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Goeppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hetzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vatlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CD","family":"Claussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Horger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2011,4,25]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1279\/1442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1279\/1443","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1279\/1442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:51:00Z","timestamp":1755226260000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,25]]},"references-count":0,"journal-issue":{"issue":"1718","published-online":{"date-parts":[[2011,4,25]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13184","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,25]]}}}