{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:43:06Z","timestamp":1760888586136,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1718","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS  UNDER STUDY: Mannan-binding lectin (MBL) and MBL-associated serine protease-2  (MASP-2) are two key components of the lectin-pathway of complement-activation.  Information on the potential role of lectin-pathway components in  carcinogenesis versus immune surveillance of cancer is scarce. This study aimed  to determine if serum concentrations of MBL and MASP-2 differ between children  with cancer and healthy age-matched controls.\n        METHODS:  In this retrospective multicentre study, MBL and MASP-2 were measured by  commercially available ELISA in frozen remnants of serum taken at diagnosis in paediatric  patients with cancer. For six diagnostic groups, these concentrations were  compared with serum concentrations of age-matched healthy controls using exact  Wilcoxon signed-rank tests.\n        RESULTS:  MBL and MASP-2 were measured in serum of 372 patients. MBL was significantly  higher in patients with solid tumours vs. controls (median, 2,799 vs. 1,917 \u03bcg\/L; P= 0.008), and MASP-2 was significantly  higher in patients with acute lymphoblastic leukaemia (406 vs. 317 \u03bcg\/L; P= 0.009), Non-Hodgkin lymphoma (361  vs. 293 \u03bcg\/L; P= 0.037) and CNS tumors  (463 vs. 296 \u03bcg\/L; P= 0.002).\n        CONCLUSIONS: These results may indicate a role of  MBL and MASP-2 in the initiation or progression of specific paediatric cancers,  while other mechanisms remain possible as well. Larger, disease-specific  studies are warranted for confirmation and for elucidation of the underlying  mechanisms.<\/jats:p>","DOI":"10.4414\/smw.2011.13191","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13191","source":"Crossref","is-referenced-by-count":11,"title":["Mannan-binding  lectin (MBL) and MBL-associated serine protease-2 in children with cancer"],"prefix":"10.57187","volume":"141","author":[{"given":"UP","family":"Fisch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hirt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ozsahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FK","family":"Niggli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LJ","family":"Schlapbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Ammann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2011,4,25]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1278\/1440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1278\/1441","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1278\/1440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:50:48Z","timestamp":1755226248000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,25]]},"references-count":0,"journal-issue":{"issue":"1718","published-online":{"date-parts":[[2011,4,25]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13191","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2011,4,25]]}}}