{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:41:21Z","timestamp":1778661681045,"version":"3.51.4"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2930","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  Patients undergoing myeloablative allogeneic haematopoietic stem cell  transplantation (HSCT) have a higher incidence of acute kidney injury (AKI).  RIFLE is a newly developed classification for AKI that includes three grades of  severity \u2013 AKI-R, AKI-I, AKI-F.\n        OBJECTIVE:  The purpose of this study was to analyse retrospectively major risk factors for  AKI at the time of myeloablative allo-HSCT and to use the RIFLE criteria to  predict mortality in myeloablative allo-HSCT.\n        METHODS: Renal  function was evaluated in 143 patients with allo-HSCT by RIFLE criteria in  order to assess the incidence, risk\u00a0factors and mortality rate of various  degrees of AKI.\n        RESULTS: The  results of this study showed that patients with hepatic veno-occlusive disease  (HVOD) have a higher incidence of AKI-F than those without HVOD (P = 0.002).  The incidence of AKI-I and AKI-F in patients with grade III-IV acute  graft-versus-host disease (aGVHD) and increased total bilirubin was  significantly higher than in those without (P = 0.001, P &lt;0.001). HVOD was an  independent risk factor of AKI-F (OR 5.058, 95% CI 1.317\u201319.424, P = 0.018),  and increased total bilirubin was an independent risk factor for AKI-F (OR  5.126, 95% CI 1.403\u201318.998, P = 0.014). Worsening RIFLE category was associated  with increased mortality of the patients in the 100 days post-transplant (P = 0.003).  In addition, 180-day survival of patients in different AKI classes was significantly  different (P = 0.0095).\n        CONCLUSION:  AKI is common in patients with myeloablative allo-HSCT and is associated with  increased risk of death. The RIFLE criteria appear to be an important tool for  stratification of these patients on the basis of death risk.<\/jats:p>","DOI":"10.4414\/smw.2011.13225","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13225","source":"Crossref","is-referenced-by-count":5,"title":["An  evaluation of the RIFLE criteria for acute kidney injury after myeloablative  allogeneic haematopoietic stem cell transplantation"],"prefix":"10.57187","volume":"141","author":[{"given":"YS","family":"Bao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SZ","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MZ","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2011,7,18]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1330\/1544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1330\/1545","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1330\/1544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:04:45Z","timestamp":1755227085000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":0,"journal-issue":{"issue":"2930","published-online":{"date-parts":[[2011,7,18]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13225","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}