{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:46:48Z","timestamp":1760298408406,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2930","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Therapeutic interventions  following severe traumatic brain injury (TBI) are substantially influenced by  complex and interwoven pathophysiological cascades involving both, local and  systemic alterations. Our main duty is to prevent secondary  progression of the primary damage. This, in turn, obliges us to actively search  and identify secondary insults related, for example, to hypoxia, hypotension,  uncontrolled hyperventilation, anaemia, and hypoglycaemia. During pharmacological  coma we must rely on specific cerebral monitoring which is indispensable in unmasking  otherwise occult changes. In addition, extended neuromonitoring (SjvO2,  ptiO2, microdialysis, transcranial Doppler sonography,  electrophysiological studies, direct brain perfusion measurement) can be used  to define individual pathological ICP levels which, in turn, will support our  decision making. Extended  neuromonitoring expands the limited knowledge derived from ICP and CPP values,  thereby allowing us to adequately adapt the type, extent and speed of different  therapeutic interventions. A more individualised and flexible treatment concept  depends on extended neuromonitoring.\n        The present review addresses current evidence in favour of extended neuromonitoring  used to guide treatment options aimed  at improving intensive care treatment of patients with severe TBI. With  increasing experience gained by the use of extended neuromonitoring in clinical  routine we may expect that the evidence obtained within the individual patient  will translate to convincing evidence on a larger scale for the entire study  population.<\/jats:p>","DOI":"10.4414\/smw.2011.13245","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T03:48:08Z","timestamp":1319687288000},"page":"w13245","source":"Crossref","is-referenced-by-count":4,"title":["Actual evidence for neuromonitoring-guided intensive  care following severe traumatic brain injury"],"prefix":"10.57187","volume":"141","author":[{"given":"J","family":"Stover","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2011,7,18]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1319\/1522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1319\/1523","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1319\/1522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:02:17Z","timestamp":1755226937000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":0,"journal-issue":{"issue":"2930","published-online":{"date-parts":[[2011,7,18]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13245","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}