{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:22:22Z","timestamp":1790716942950,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"4546","license":[{"start":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T00:00:00Z","timestamp":1320624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  Intra-operative parathyroid hormone (PTH) levels have successfully been used to  assess surgical ablation of parathyroid adenomas, the use of this same test to  predict preservation of viable gland has not been widely used.\n        AIM: to test the  sensitivity and specificity of intraoperative rapid PTH assay test in predicting permanent  postoperative hypoparathyroidism, and applicability to guide the search for  inadvertently removed parathyroid glands for possible auto transplantation.\n        PATIENTS AND METHODS: 52 patients undergoing total thyroidectomy for non-malignant thyroid  diseases were included. Intraoperative rapid PTH assay test was performed. If  levels were reduced, or less than 3 parathyroid glands were detected, removed  thyroid gland was examined for unintentionally removed parathyroid tissue for  possible auto transplantation.\n        RESULTS: There  was a strong correlation between intraoperative rapid PTH assays and those  taken 24 hours after surgery, 16 out of 52 patients had reduction of the  PTH intraoperatively to levels below 25 pg\/ml, of them, 11 patients (who had  values between 15\u201324\u00a0pg\/ml) recovered to normal PTH levels within 4 weeks,  while the 5 patients with intraoperative PTH levels below 15 pg\/ml failed to  regain normal PTH levels up to 12 weeks postoperatively, even in those patients  where parathyroid tissue was auto transplantated. The 4 patients who had  parathyroid tissue reimplanted intraoperatively restored some of their  parathyroid function as indicated by relative rise of their PTH levels, but did  not reach even the low normal levels. (ROC) curve for prediction of early  hypoparathyroidism using intraoperative rapid PTH assay was statistically  highly significant with optimal cutoff value for predicting early hypocalcaemia level &lt;27 pg\/ml, (sensitivity 100%, specificity  68.2%). (ROC) curves for predicting permanent hypoparathyroidism using  intraoperative rapid PTH assay or standard PTH assay taken 24 hours after  surgery were statistically significant with optimal cutoff value PTH level  &lt;12 pg\/ml on the intraoperative PTH curve or &lt;15 pg\/ml on the  postoperative PTH curve (sensitivity 100%, specificity 100%).\n        CONCLUSION:  Intraoperative PTH assay may allow intraoperative monitoring of parathyroid  function, predicting postoperative outcomes, may identify patients at risk of  developing postoperative hypoparathyroidism, guiding surgeons to re-examine  removed specimens for inadvertently removed parathyroid tissue with possible  auto transplantation, or more practically a guide to early replacement therapy  to prevent hypocalcaemia,  leading to  safe and early hospital discharge. Limitations in our study to be reconsidered  in further studies, are relative small sample size, inability for randomisation,  and the variable values reported for the cut off value of PTH causing  hypocalcaemic symptoms needing intervention.\n        \u00a0\n        Level of evidence 1b (individual  inception study with &gt;80% F\/U).<\/jats:p>","DOI":"10.4414\/smw.2011.13299","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T17:30:37Z","timestamp":1320773437000},"page":"w13299","source":"Crossref","is-referenced-by-count":6,"title":["Intraoperative  parathyroid hormone as an indicator for parathyroid gland preservation in\u00a0thyroid surgery"],"prefix":"10.57187","volume":"141","author":[{"given":"H","family":"Fathey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"El-Ashri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HB","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2011,11,7]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1382\/1648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1382\/1649","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1382\/1648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:20:09Z","timestamp":1755228009000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,7]]},"references-count":0,"journal-issue":{"issue":"4546","published-online":{"date-parts":[[2011,11,7]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2011.13299","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,7]]}}}