{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:13:51Z","timestamp":1758636831932,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0304","license":[{"start":{"date-parts":[[2012,1,15]],"date-time":"2012-01-15T00:00:00Z","timestamp":1326585600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Transmissible  spongiform encephalopathies are fatal neurodegenerative diseases that affect mammals  including humans. The\u00a0proteinaceous nature of the infectious agent, the prion,  and its propagation, challenge established dogmas in biology. It is now widely  accepted that prion diseases are caused by unconventional agents principally composed  of a misfolded host-encoded protein, PrP. Surprisingly, major break-throughs in  prion research came from studies on functionally unrelated proteins in yeast  and filamentous fungi. Aggregates composed of these proteins act as epigenetic  elements of inheritance that can propagate their alternative states by a  conformational switch into an ordered \u00df-sheet rich polymer just like mammalian  prions. Since their discovery prions of lower eukaryotes have provided  invaluable insights into all aspects of prion biogenesis. Importantly, yeast  prions provide proof-of-principle that distinct protein conformers can be  infectious and can serve as genetic elements that have the capacity to encipher  strain specific information. As a powerful and tractable model system, yeast  prions will continue to increase our understanding of prion-host cell  interaction and potential mechanisms of protein-based epigenetic inheritance.<\/jats:p>","DOI":"10.4414\/smw.2012.13505","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T10:03:09Z","timestamp":1327399389000},"page":"w13505","source":"Crossref","is-referenced-by-count":1,"title":["Creutzfeldt-Jakob  disease and mad cows: lessons learnt from yeast cells"],"prefix":"10.57187","volume":"142","author":[{"given":"Julia","family":"Hofmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Grassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Arndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Vorberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,1,15]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1412\/1708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1412\/1709","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1412\/1708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:26:33Z","timestamp":1755228393000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,15]]},"references-count":0,"journal-issue":{"issue":"0304","published-online":{"date-parts":[[2012,1,16]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13505","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,1,15]]}}}