{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:23:45Z","timestamp":1761823425765,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0708","license":[{"start":{"date-parts":[[2012,2,12]],"date-time":"2012-02-12T00:00:00Z","timestamp":1329004800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Thrombosis  is a rare but serious complication of stent implantation in atherosclerotic  arteries, affecting both bare-metal and drug-eluting stents. Diagnostic criteria  for stent thrombosis have recently been updated with the time and probability  of the event being considered as crucial parameters. To be considered as  \u201cdefinite\u201d, the diagnosis of stent thrombosis has to be confirmed by  angiography or histology. This statement position has clearly rendered more  difficult the clinical assessment of stent thrombosis in randomised clinical  trials. Considering these limitations, stent thrombosis represents a dramatic complication  for both patients and cardiologists. In coronary plaques, thrombosis is often  associated with death, acute coronary syndromes and arrhythmias. For these  reasons, the pharmacological improvement of this outcome represents a  \u201chot-topic\u201d field for research. Among several medications, statins have been  shown to potentially reduce the incidence of coronary stent thrombosis in  humans. However, randomised clinical trials focussing on \u201cdefinite\u201d diagnosis  are still needed to confirm these promising results. In addition, the use of  statins in patients implanted with stents in other arteries is largely  unexplored. Finally, statin-eluting stents (only tested in pigs) have to be  evaluated in other animal models and human beings. Therefore, a clear recommendation  on the use of statins to prevent stent thrombosis is not available and caution  should be used. The \u201cpleiotropic\u201d anti-atherosclerotic properties of statins  might represent a crucial investigation field to pathophysiologically clarify  the role of statins in stent complications.<\/jats:p>","DOI":"10.4414\/smw.2012.13525","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T01:27:03Z","timestamp":1329701223000},"page":"w13525","source":"Crossref","is-referenced-by-count":4,"title":["Statins and stent thrombosis"],"prefix":"10.57187","volume":"142","author":[{"given":"Vincent","family":"Braunersreuther","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Mach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Montecucco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,2,12]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1433\/1750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1433\/1751","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1433\/1750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:34:15Z","timestamp":1755228855000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,12]]},"references-count":0,"journal-issue":{"issue":"0708","published-online":{"date-parts":[[2012,2,13]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13525","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,2,12]]}}}