{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:22:21Z","timestamp":1787012541969,"version":"build-2736575974"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1112","license":[{"start":{"date-parts":[[2012,3,11]],"date-time":"2012-03-11T00:00:00Z","timestamp":1331424000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Systemic  vasculitides are rare and potentially life-threatening diseases. Granulomatosis  with polyangiitis (GPA; formerly Wegener\u2019s granulomatosis) and Churg Strauss  syndrome (possibly to be renamed eosinophilic granulomatosis with polyangiitis;  EGPA) are the 2\u00a0chief systemic vasculitides which may involve the upper respiratory  tract. Chronic allergic rhinitis and nasal polyposis in EGPA, and\u00a0recurrent  sinusitis and\/or otitis in both conditions, are not specific and can thus  represent real diagnostic challenges if they are the first manifestations of  the disease. Nasal septum perforation, saddle nose deformity and\/or subglottic  stenosis (SGS), although not totally specific, are more suggestive of GPA.  Because upper airway manifestations often tend to be refractory to systemic  therapy and\/or to linger, local treatment represents a major aspect of  management of the condition, especially for patients with SGS.<\/jats:p>","DOI":"10.4414\/smw.2012.13541","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T14:23:21Z","timestamp":1332426201000},"page":"w13541","source":"Crossref","is-referenced-by-count":11,"title":["Vasculitis of the upper airways1"],"prefix":"10.57187","volume":"142","author":[{"given":"Christian","family":"Pagnoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus E","family":"Wolter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,3,11]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1444\/1772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1444\/1773","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1444\/1772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:37:59Z","timestamp":1755229079000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,11]]},"references-count":0,"journal-issue":{"issue":"1112","published-online":{"date-parts":[[2012,3,12]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13541","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,11]]}}}