{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:45Z","timestamp":1790957745221,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1112","license":[{"start":{"date-parts":[[2012,3,11]],"date-time":"2012-03-11T00:00:00Z","timestamp":1331424000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Gastroesophageal reflux is a  common condition affecting many patients in different parts of the world. It  usually presents with the classic manifestations of heartburn and  regurgitation; however, in some it can also present with extraesophageal  manifestations such as chronic cough, laryngitis, asthma or chest pain.  Commonly employed diagnostic tests such as esophagogastroduodenoscopy and ambulatory pH or impedance  monitoring in gastroesophageal reflux, are less useful in extraesophageal syndromes due to their  poor sensitivity and specificity. In contrast, empiric trials of PPI\u2019s are  shown to be cost effective; however, patients may require long-term treatment  to establish effectiveness. Diagnostic testing with pH and impedance monitoring  are commonly reserved for patients with partial or poor response to the initial  treatment with PPI\u2019s. Poor response to PPI therapy may be an important  indicator for non-gastroesophageal reflux causes for patients\u2019 symptoms and should initiate a  search for other potential causes.<\/jats:p>","DOI":"10.4414\/smw.2012.13544","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T08:11:55Z","timestamp":1333354315000},"page":"w13544","source":"Crossref","is-referenced-by-count":9,"title":["Extraesophageal  manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain"],"prefix":"10.57187","volume":"142","author":[{"given":"Elif","family":"Saritas Yuksel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vaezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,3,11]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1450\/1784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1450\/1785","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1450\/1784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:39:13Z","timestamp":1755229153000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,11]]},"references-count":0,"journal-issue":{"issue":"1112","published-online":{"date-parts":[[2012,3,12]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13544","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,11]]}}}