{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:37:30Z","timestamp":1791333450739,"version":"4.3.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1920","license":[{"start":{"date-parts":[[2012,5,6]],"date-time":"2012-05-06T00:00:00Z","timestamp":1336262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS  UNDER STUDY: Up to 20% of elderly patients present to the emergency department  (ED) with non-specific complaints (NSC), such as \u201cgeneralised weakness\u201d, the  majority suffering from serious conditions requiring timely intervention. Little  is known about the use and influence of diuretics and  renin-angiotensin-aldosterone (RAAS) blockade on morbidity in those patients. The\u00a0hypothesis was tested that the use of diuretics and RAAS blockade could be  associated with an increased incidence of serious conditions in those patients.\n        METHODS:  During a 23-month period, all adult non-trauma patients with an Emergency  Severity Index (ESI) of 2 or 3 were prospectively enrolled. Serious conditions were  defined as potentially life-threatening conditions or conditions requiring  early intervention to prevent further morbidity and mortality.\n        RESULTS: Study  population consisted of 633 patients with median age 82 years, median Charlson  comorbidity index 2. 59% of all subjects suffered from a serious condition. 299  subjects (47.2%) used diuretics, of which 65.6% suffered from a serious  condition. Combination therapy of RAAS blockade and diuretics was found in 158  subjects (24.9%), 70.3% of which suffered from a serious condition. The intake of  two or more diuretics, loop diuretics and a combination therapy with diuretics  and RAAS blockade were associated with an increased risk for serious condition  (p = 0.036; p = 0.021; p = 0.004).\n        CONCLUSIONS:  Treatment with two or more diuretics, loop diuretics, or a combination therapy  with RAAS blockade and diuretics are independently associated with serious  condition and therefore should be recognized as \u201cred flags\u201d in elderly patients  presenting to the ED with NSC.<\/jats:p>","DOI":"10.4414\/smw.2012.13568","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T16:02:49Z","timestamp":1337011369000},"page":"w13568","source":"Crossref","is-referenced-by-count":5,"title":["Diuretic  use, RAAS blockade and morbidity in elderly patients presenting to the  Emergency Department with non-specific complaints"],"prefix":"10.57187","volume":"142","author":[{"given":"Juliane M.","family":"Ruedinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Maile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto W.","family":"Kressig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bingisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,5,6]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1478\/1840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1478\/1841","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1478\/1840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:45:12Z","timestamp":1755229512000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,6]]},"references-count":0,"journal-issue":{"issue":"1920","published-online":{"date-parts":[[2012,5,7]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13568","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,6]]}}}