{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:18:35Z","timestamp":1755793115628,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1516","license":[{"start":{"date-parts":[[2012,4,8]],"date-time":"2012-04-08T00:00:00Z","timestamp":1333843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  There is considerable heterogeneity in the use of chemotherapy in early breast  cancer (BC), despite international recommendations issued from the NCCN, NIH  and the St.Gallen bi-annual conference.\n        METHODS:  We included 1,535 patients from seven Swiss cancer registries between 2003 and  2005 receiving chemotherapy for stage I to III BC.  Chemotherapy was categorised into (a) FAC\/FEC, anthracyclines followed by CMF  or anthracycline-taxane combinations (FAC-T) (781 patients) and (b) other  chemotherapy regimens such as CMF\/AC (EC) (754 patients). Predictors for  choosing FAC-T over non-FAC-T chemotherapy were separately determined in all  patients and in ER-negative patients (n = 496) by multivariate logistic  regression analysis.\n        RESULTS:  The use of FAC-T increased significantly over time, from 44% in 2003 to 55% in  2005. BC stage III (versus stage\u00a0I-II) and nodal positivity were the  predominant predictors for using FAC-T chemotherapy in the adjusted model (odds  ratio (OR) 4.1, 95%-confidence intervals (CI) 2.6\u20136.3 and OR 3.0, 95%-CI 2.0\u20134.4,  respectively). In high-risk ER-negative BC patients, poor histological  differentiation was more important to choose FAC-T chemotherapy (OR 3.8, 95%-CI  1.9\u20137.5) than tumour stage or nodal status. The use of FAC-T chemotherapy  varied substantially among the seven geographic regions, from 20% in rural  Grisons-Glarus to 73% in Zurich.\n        CONCLUSIONS:  Tumour biology is a predominant factor for choosing FAC-T over older  chemotherapy regimens in patients with ER-negative early BC, but improvements  should be made to reduce the substantial regional heterogeneity. Further  epidemiological studies should assess how the use of FAC-T chemotherapy is  affecting clinical outcome in patients with early BC and different risk  profiles.<\/jats:p>","DOI":"10.4414\/smw.2012.13571","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T05:57:14Z","timestamp":1334210234000},"page":"w13571","source":"Crossref","is-referenced-by-count":0,"title":["A population-based study on the patterns of use of different\u00a0chemotherapy  regimens in patients with early breast cancer"],"prefix":"10.57187","volume":"142","author":[{"given":"Markus","family":"Joerger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Dehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Savidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bouchardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Frick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Konzelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Th\u00fcrlimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,4,8]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1468\/1820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1468\/1821","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1468\/1820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:43:04Z","timestamp":1755229384000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,8]]},"references-count":0,"journal-issue":{"issue":"1516","published-online":{"date-parts":[[2012,4,9]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13571","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,4,8]]}}}