{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:45:26Z","timestamp":1759099526946,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1920","license":[{"start":{"date-parts":[[2012,5,6]],"date-time":"2012-05-06T00:00:00Z","timestamp":1336262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND: Patients  who have acute coronary syndromes with or without ST-segment elevation have  high rates of major vascular events. We evaluated the efficacy of early clopidogrel administration (300 mg) (&lt;24 hours) when given with aspirin in such patients.\n        METHODS: We  included 30,243 patients who had an acute coronary syndrome with or without ST  segment elevation. Data on early clopidogrel administration were available for  24,463 (81%). Some 15,525 (51%) of the total cohort were administrated  clopidogrel within 24h of admission.\n        RESULTS:  In-hospital death occurred in 2.9% of the patients in the early clopidogrel  group treated with primary PCI and in 11.4% of the patients in the other group  without primary percutaneous  coronary intervention (PCI) and no early clopidogrel. The unadjusted  clopidogrel odds ratio (OR) for mortality was 0.31 (95% confidence interval  0.27\u20130.34; p &lt;0.001). Incidence of  major adverse cardiac death (MACE) was 4.1% in the early clopidogrel group  treated with 1\u00b0PCI and 13.5% in the other group without primary PCI and no  early clopidogrel (OR 0.35, confidence interval 0.32\u20130.39, p &lt;0.001). Early clopidogrel administration and PCI were the  only treatment lowering mortality as shown by mutlivariate analysis.\n        CONCLUSIONS: The early  administration of the anti-platelet agent clopidogrel in patients with acute  coronary syndromes with or without ST-segment elevation has a beneficial effect on mortality  and major adverse cardiac events. The lower mortality rate and incidence of  MACE emerged with a combination of primary PCI and early clopidogrel administration.<\/jats:p>","DOI":"10.4414\/smw.2012.13573","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T16:02:49Z","timestamp":1337011369000},"page":"w13573","source":"Crossref","is-referenced-by-count":2,"title":["Dramatic effect of early clopidogrel administration in\u00a0reducing mortality and MACE rates in ACS patients"],"prefix":"10.57187","volume":"142","author":[{"given":"Jean Christophe","family":"Stauffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Jacques","family":"Goy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Duvoisin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Radovanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Rickli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Erne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,5,6]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1479\/1842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1479\/1843","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1479\/1842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:45:24Z","timestamp":1755229524000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,6]]},"references-count":0,"journal-issue":{"issue":"1920","published-online":{"date-parts":[[2012,5,7]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13573","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,5,6]]}}}