{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:52:09Z","timestamp":1792158729973,"version":"4.4.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2122","license":[{"start":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T00:00:00Z","timestamp":1337472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Systemic  AA amyloidosis is a long-term complication of several chronic inflammatory  disorders, including rheumatoid arthritis, ankylosing spondylitis,  autoinflammatory syndromes, Crohn\u2019s disease, malignancies and conditions  predisposing to recurrent infections. Organ damage results from the  extracellular deposition of proteolytic fragments of the acute-phase reactant  serum amyloid A (SAA) as amyloid fibrils. A sustained high concentration of SAA  is the prerequisite for developing AA amyloidosis. However, only a minority of  patients with long-standing inflammation actually presents with this  complication, pointing to the existence of disease-modifying factors, the best characterised  of which being SAA1 genotype. The  kidneys, liver and spleen are the main target organs of AA amyloid deposits. In  more than 90% of patients proteinuria, nephrotic syndrome and\/or renal  dysfunction dominate the clinical picture at onset. If not effectively treated,  this disease invariably leads to end stage kidney disease and renal replacement  therapy, that are still associated with a poor outcome.\n        Although  the incidence of AA in rheumatoid arthritis and other chronic arthritides has  continuously decreased over the past ten years, thanks to the increasing  availability of more effective anti-inflammatory and immunosuppressive therapies,  AA remains a life-threatening disease with several areas of uncertainty and  unmet needs, deserving continuous efforts at prevention and effective treatment.  The deeper understanding of the molecular mechanisms of amyloid formation and  regression is now driving the development of novel treatments targeting  different steps in the amyloidogenic cascade. These therapies will hopefully  improve the quality of life and outcome of these patients in a near future.<\/jats:p>","DOI":"10.4414\/smw.2012.13580","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T01:21:44Z","timestamp":1339464104000},"page":"w13580","source":"Crossref","is-referenced-by-count":41,"title":["AA amyloidosis: basic knowledge, unmet needs  and\u00a0future\u00a0treatments"],"prefix":"10.57187","volume":"142","author":[{"given":"Laura","family":"Obici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Merlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,5,20]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1486\/1856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1486\/1857","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1486\/1856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:47:01Z","timestamp":1755229621000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,20]]},"references-count":0,"journal-issue":{"issue":"2122","published-online":{"date-parts":[[2012,5,21]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13580","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,20]]}}}