{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:59:13Z","timestamp":1792159153545,"version":"4.4.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2122","license":[{"start":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T00:00:00Z","timestamp":1337472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Interleukin  1, one of the first cytokines discovered in the 1980s, and a potent mediator of  fever, pain and inflammation, is at present experiencing a revival in biology  and medicine. Whereas the mechanism of activation and secretion of interleukin  1\u03b2, which\u00a0critically regulates the  function of this molecule, has remained mysterious for some 30 years following  its discovery, the identification of a new cytoplasmic complex of proteins  regulating IL-1\u03b2 activation and secretion has  carried our understanding of the role of IL1 in biology and disease one big  step further. The inflammasomes, recently identified innate immune complexes  that sense intracellular danger- (e.g. uric acid, ATP, cytoplasmic DNA) or  pathogen-associated molecular patterns (e.g. muramyl dipeptide, flagellin, anthrax  lethal toxin), are now known to be responsible for triggering  inflammation  in response to several molecular patterns, including, for example, uric acid, a  danger-associated molecular pattern and trigger of gout. Dysregulation of  inflammasome function is however also the cause of a family of genetic  autoinflammatory diseases known as cryopyrin-associated periodic syndromes  (CAPS) characterised by recurrent episodes of fever, urticarial-like skin  lesions, systemic inflammation and arthritis. In mouse models recapitulating  mutations observed in CAPS, neutrophilic inflammation of the skin is a cardinal  feature, in\u00a0a manner similar to several autoinflammatory diseases with skin  involvement such as PAPA (pyoderma gangrenosum, acne and pyogenic arthritis) and  Schnitzler\u2019s syndrome, in which IL-1\u03b2 very probably  plays a pathogenic role. In this article the role of the inflammasome in IL-1  biology, autoinflammation and disease is reviewed, together with new avenues  for the therapy of these diseases.\n        \u00a0\n        \nKey words:\ninflammation; interleukin-1; innate immunity; inflammasome; skin; fever\n<\/jats:p>","DOI":"10.4414\/smw.2012.13590","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T01:21:44Z","timestamp":1339464104000},"page":"w13590","source":"Crossref","is-referenced-by-count":45,"title":["Interleukin-1,  inflammasomes, autoinflammation and\u00a0the\u00a0skin"],"prefix":"10.57187","volume":"142","author":[{"given":"Emmanuel","family":"Contassot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dietmar","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,5,20]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1495\/1874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1495\/1875","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1495\/1874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:49:03Z","timestamp":1755229743000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,20]]},"references-count":0,"journal-issue":{"issue":"2122","published-online":{"date-parts":[[2012,5,21]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13590","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,20]]}}}