{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:38:07Z","timestamp":1777109887427,"version":"3.51.4"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2526","license":[{"start":{"date-parts":[[2012,6,17]],"date-time":"2012-06-17T00:00:00Z","timestamp":1339891200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS  UNDER STUDY: 8 years after discovery of osteonecrosis of the jaw associated  with bisphosphonate therapy a lot of experience   has  been  garnered in treating 112 patients with this  disease.  This disease, although  uncommon, is still a burden for the patient as well as the treating specialists  and an adequate standardised classification as well as therapy does not exist.  This article presents a summary of collected patient data,  garnered experience and consequential changes  in knowledge, in diagnostic measures and therapy.\n        METHODS:  The data of in total 112 patients referred to the Special Clinics for patients  with bisphosphonate-associated lesions of the jaw was retrospectively analysed  and compared with data from the literature.\n        RESULTS:  In total, 110 patients, 70% women, were included in the data analysis. A  quarter of those patients had osteoporosis as the underlying disease, more than  half of all patients had extractions as the local influencing factor. The  lesion was localised in the mandible in three quarters of all patients and  almost all patients showed clinical signs of infection. In total, 58% of all  patients were treated surgically with a   complete remission rate of 78%   over 7 years.\n        CONCLUSIONS:  This summary of patient data and literature shows that knowledge about  bisphosphonate-associated osteopathology of the jaw  becomes more and more specific. The range of  drugs associated with this disease has increased, but also therapeutic options  show more and more success. Classifications, published shortly after the discovery  of BRONJ need to be revised and  new  knowledge included.<\/jats:p>","DOI":"10.4414\/smw.2012.13605","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T13:42:22Z","timestamp":1340804542000},"page":"w13605","source":"Crossref","is-referenced-by-count":16,"title":["Osteopathology  of the jaw associated with bone resorption inhibitors: what have we learned in  the last 8 years?"],"prefix":"10.57187","volume":"142","author":[{"given":"Christine","family":"Jacobsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Metzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim\u00a0Anton","family":"Obwegeser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Zemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u00a0Wilhelm","family":"Gr\u00e4tz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,6,17]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1513\/1910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1513\/1911","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1513\/1910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:52:39Z","timestamp":1755229959000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,17]]},"references-count":0,"journal-issue":{"issue":"2526","published-online":{"date-parts":[[2012,6,18]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13605","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,17]]}}}