{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:19:37Z","timestamp":1755793177285,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2930","license":[{"start":{"date-parts":[[2012,7,15]],"date-time":"2012-07-15T00:00:00Z","timestamp":1342310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Depending  on the populations studied and the definitions applied, the prevalence of  treatment-resistant hypertension varies from 10% to 15%, but is higher in  conditions associated with increased sympathetic drive, such as obesity,  obstructive sleep apnoea, diabetes or renal dysfunction. The Symplicity studies recently demonstrated that  reducing sympathetic tone by intravascular renal denervation is feasible in treatment-resistant  hypertension, but failed to provide conclusive evidence on the size and  durability of the antihypertensive, renal and sympatholytic effects, long-term  safety, quality of life, the possibility to relax antihypertensive drug  treatment, cost-effectiveness, and long-term hard cardiovascular-renal  outcomes. Renal denervation should therefore only be offered within a clinical  research context at highly skilled tertiary referral centres that participate  in international registries constructed independent of the manufacturers.<\/jats:p>","DOI":"10.4414\/smw.2012.13638","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13638","source":"Crossref","is-referenced-by-count":0,"title":["Renal denervation: time  to open Pandora\u2019s box"],"prefix":"10.57187","volume":"142","author":[{"given":"Yu-Mei","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Asayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,7,15]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1532\/1948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1532\/1949","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1532\/1948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:56:37Z","timestamp":1755230197000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,15]]},"references-count":0,"journal-issue":{"issue":"2930","published-online":{"date-parts":[[2012,7,16]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13638","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,7,15]]}}}