{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:00:22Z","timestamp":1757700022333,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3132","license":[{"start":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T00:00:00Z","timestamp":1343520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is  the most frequent form of primary liver cancer and chronic infection with hepatitis  C virus is one of the main risk factors for HCC. This study analyses the characteristics  of the patients with chronic hepatitis\u00a0C participating in the Swiss Hepatitis C  Cohort Study who developed HCC.\n        METHODS: Analysis of the database of the Swiss  Hepatitis C Cohort Study, a multicentre study that is being carried out in  eight major Swiss hospitals since the year 2000. Patients with chronic  hepatitis C and HCC were regrouped and compared to the patients without HCC.\n        RESULTS: Among the 3,390 patients of the cohort, 130  developed an HCC. Age was one of the determining factors. Cirrhosis and its  complications ascites and porto-systemic encephalopathy were associated with  HCC. Males presented a higher risk for HCC than females. Alcohol consumption  was associated with HCC. Diabetes mellitus was an important risk factor,  especially in patients with low fibrosis. Patients with Hepatitis C genotype 2  had significantly less HCC than patients with other genotypes. A low socioeconomic  status (income, education, profession) was associated with HCC.\n        CONCLUSIONS: Beside the expected characteristics (age,  gender, cirrhosis, alcohol), these data stress the role of diabetes mellitus  and reveal the importance of low socioeconomic status as a risk factor for HCC  in Swiss patients infected with hepatitis C virus. This vulnerable population  should be closely monitored.<\/jats:p>","DOI":"10.4414\/smw.2012.13651","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13651","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics  of patients with chronic hepatitis C who develop hepatocellular carcinoma"],"prefix":"10.57187","volume":"142","author":[{"given":"Lorenz","family":"Kuske","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armand","family":"Mensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Negro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Semela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius","family":"Moradpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Jean","family":"Mal\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus H","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Malinverni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Cerny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,7,29]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1550\/1984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1550\/1985","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1550\/1984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:00:24Z","timestamp":1755230424000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,29]]},"references-count":0,"journal-issue":{"issue":"3132","published-online":{"date-parts":[[2012,7,30]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13651","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,7,29]]}}}