{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:22:39Z","timestamp":1790706159115,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3132","license":[{"start":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T00:00:00Z","timestamp":1343520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Malignant  hyperthermia (MH) is a subclinical myopathy, usually triggered by volatile  anaesthetics and depolarising muscle relaxants. Clinical symptoms are variable,  and the condition is sometimes difficult to identify. Nevertheless, rapid  recognition and specific as well as symptomatic treatment are crucial to avoid  a lethal outcome. Molecular genetic investigations have confirmed the skeletal  muscle type ryanodine receptor to be the major MH locus with more than 70% of  MH families carrying a mutation in this gene. There is no screening method to  test for MH, as current tests are invasive (open muscle biopsy) or restricted  to MH families with known MH-associated mutations (molecular genetic testing).\n        The  prevalence of the MH trait is unknown, because the clinical penetrance after  contact with triggering agents is very variable. More recently, MH mutations  have been associated with rhabdomyolysis following statin therapy or with  non-pharmacological triggering, such as exertional heat stroke.<\/jats:p>","DOI":"10.4414\/smw.2012.13652","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13652","source":"Crossref","is-referenced-by-count":9,"title":["Malignant  hyperthermia"],"prefix":"10.57187","volume":"142","author":[{"given":"Oliver","family":"Bandschapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,7,29]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1549\/1982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1549\/1983","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1549\/1982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:00:12Z","timestamp":1755230412000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,29]]},"references-count":0,"journal-issue":{"issue":"3132","published-online":{"date-parts":[[2012,7,30]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13652","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,29]]}}}