{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:09:27Z","timestamp":1768514967094,"version":"3.49.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3132","license":[{"start":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T00:00:00Z","timestamp":1343520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  Hydroxyethyl starch (HES) is in widespread clinical use for volume therapy with  colloids. According to the most recent meta-analysis performed in 2010,  published studies are of poor quality and report too few events to reliably  estimate the benefits or risks of administering 6% HES 130\/0.4. As results from  new trials, reporting on a large number of events became available in 2011 and  2012, an updated meta-analysis was performed.\n        METHODS:  Randomised controlled trials comparing the effects of 6% HES 130\/0.4 with other  colloid or crystalloid solutions were analysed for pooled effect size on  mortality in eligible studies published up to 20 February 2012.\n        RESULTS:  Overall, 13 studies reporting 1,131 participants met the inclusion criteria.  The weight of evidence contributed by the two new trials was 51.3%. The pooled  relative risk (RR) for mortality increased to 1.14 with a 95% confidence  interval (CI) of 0.89 to 1.46. Publication bias favoring HES 130\/0.4 was  present (p = 0.038). Adjustment for the observed publication bias increased the  RR for mortality to 1.25 (CI, 0.98 to 1.58; p = 0.069). No heterogeneity was  found (I2, 0%; CI, 0% to 32%; p = 0.81).\n        CONCLUSIONS:  Large-scale trials should help more precisely to determine the effect of HES  130\/0.4 on mortality. In the interim, best current evidence suggests a trend  toward higher mortality among HES 130\/0.4 recipients.<\/jats:p>","DOI":"10.4414\/smw.2012.13656","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13656","source":"Crossref","is-referenced-by-count":4,"title":["Mortality  after hydroxyethyl starch 130\/0.4 infusion: an\u00a0updated meta-analysis of  randomized trials"],"prefix":"10.57187","volume":"142","author":[{"given":"Christian Josef","family":"Wiedermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Joannidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,7,29]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1555\/1994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1555\/1995","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1555\/1994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:01:26Z","timestamp":1755230486000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,29]]},"references-count":0,"journal-issue":{"issue":"3132","published-online":{"date-parts":[[2012,7,30]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13656","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,29]]}}}