{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:20:25Z","timestamp":1755793225536,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3334","license":[{"start":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T00:00:00Z","timestamp":1344729600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>AIM:  Sustained elevation of resting heart rate (RHR) is thought to promote the  initiation and progression of coronary artery disease (CAD). The aim of this  paper is to test the hypothesis whether elevated RHR correlates with the  presence and the extent of CAD in patients evaluated for CAD.\n        METHODS  AND RESULTS: The association between RHR and CAD findings and myocardial perfusion  SPECT (MPS) was tested in 1,465 patients. Patients with atrial fibrillation,  pacemaker rhythm and treatment with negative chonotropic drugs were excluded.  Standard scores for MPS evaluation were used.\n        CAD  findings of myocardial ischaemia or scar were present in 408 patients (28%).  The prevalence of CAD finding at MPS was not higher among patients with RHR  above the median value of 79 bpm compared to patients with lower RHR (28% vs  28%; p\u00a0=\u00a01.00). The extent of myocardial ischaemia and scar did not increase  with higher quartiles of RHR. In contrast, the presence of other established  cardiovascular risk factors such as diabetes, male gender, more advanced age  and presence of CAD symptoms such as angina and dyspnoea were independent  predictors of CAD findings (p &lt;0.05 for all).\n        CONCLUSION:  Elevated RHR is not associated with the presence and the extent of CAD in  patients evaluated for suspected but previously unknown CAD, suggesting that  the impact of a higher RHR on mortality may be linked with other factors than  only CAD itself.<\/jats:p>","DOI":"10.4414\/smw.2012.13660","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13660","source":"Crossref","is-referenced-by-count":2,"title":["Relationship  between the resting heart rate and the extent of coronary artery disease as  assessed by myocardial perfusion SPECT"],"prefix":"10.57187","volume":"142","author":[{"given":"Angela","family":"Kohler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Muzzarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"M\u00fcller-Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Brinkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael\u00a0J.","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,8,12]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1558\/2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1558\/2001","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1558\/2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:02:07Z","timestamp":1755230527000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,12]]},"references-count":0,"journal-issue":{"issue":"3334","published-online":{"date-parts":[[2012,8,13]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13660","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,8,12]]}}}