{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T19:27:49Z","timestamp":1775330869332,"version":"3.50.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3334","license":[{"start":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T00:00:00Z","timestamp":1344729600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Prior to  the introduction of chemotherapy, tuberculosis management relied upon  aerotherapy, heliotherapy and good nutrition. This \u201ctreatment\u201d, exemplified  by the regimen applied in Swiss and other European mountain resorts, is  described by Thomas Mann in the book \u201cThe Magic Mountain\u201d. Tuberculosis  chemotherapy began in 1944 with the introduction of streptomycin and  para-amino-salicylic acid, later augmented by isoniazid. Early experience taught physicians that  treatment must be given with multiple drugs to prevent emergence of resistance  and that prolonged treatment adherence for 18\u201324 months was needed for a permanent  cure of tuberculosis. Between 1970 and 1980 rifampicin was introduced and with  pyrazinamide it made \u201cshort-course\u201d  treatment possible. For 30  years, a 6-month directly observed treatment short-course (DOTS) based on the  three compounds isoniazid,  rifampicin and pyrazinamide was the foundation of tuberculosis control  strategies world-wide, and in recent years this was supplemented with  ethambutol in view of increasing rates of isoniazid resistance. However, even 6  months of treatment is too long to easily ensure the compliance necessary to permanently  cure tuberculosis. The recent spread of the HIV\/AIDS epidemic has placed  tuberculosis programmes under severe pressure and is accompanied by an increase  in drug-resistance making tuberculosis virtually untreatable in some instances.  In 2004 the first of a new generation of anti-tuberculosis drugs entered  clinical evaluation. A series of clinical trials, often conducted at sites in Cape Town, South    Africa, has shown them to be efficacious and  hold promise of being able to shorten tuberculosis treatment and treat  drug-resistant tuberculosis. Development and assessment of these drugs is  ongoing but there is renewed hope that these new drugs and regimens will assist  in finally conquering tuberculosis, preventing a return to Magic Mountain  where sunshine and fresh air was all that could be offered to patients.<\/jats:p>","DOI":"10.4414\/smw.2012.13665","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T14:22:36Z","timestamp":1346682156000},"page":"w13665","source":"Crossref","is-referenced-by-count":7,"title":["From Magic Mountain to Table Mountain"],"prefix":"10.57187","volume":"142","author":[{"given":"Andreas","family":"Diacon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Von Groote-Bidlingmaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter\u00a0R.","family":"Donald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,8,12]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1571\/2026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1571\/2027","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1571\/2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:05:08Z","timestamp":1755230708000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,12]]},"references-count":0,"journal-issue":{"issue":"3334","published-online":{"date-parts":[[2012,8,13]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13665","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,12]]}}}