{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:36:35Z","timestamp":1787031395513,"version":"build-2736575974"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3940","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>PRINCIPLES:  During the past years our group built a care network  for patients with pituitary tumours with referrals from  the midlands and the central part of Switzerland, comprising about 1.6  million inhabitants. The purpose of this retrospective observational study with  longitudinal data is to review the experience of pituitary surgery and the  operative outcome within this    Swiss-wide largest network.\n        METHODS: A  total of 182 patients operated at the Neurosurgical Department of the  Kantonsspital Aarau 2005\u20132010 were included in this study. The  follow-up was 3.6\u00b11.6  years.\n        RESULTS: The  following lesions were found: non-functioning adenoma (n = 114; 63%);  macroprolactinoma (n = 18; 10%); microprolactinoma (n = 11; 6%); acromegaly (n  = 11; 6%), Cushing\u2019s disease (n = 7; 4%); Rathke\u2019s cleft cyst (RCC; n = 9; 5%);  others (n = 12; 7%). Intraoperative MRI (iMRI) was used in 115 (63%) patients.  Preoperatively, hypopituitarism was found in 105 (58%) patients. Postoperative  recovery of defunct axes was detected in 48%. Visual field and visual acuity  deficits due to optic pathway compression by tumour were detected in 48% and  41% of the patients, respectively. Postoperative recovery of visual function  was seen in 89%. The increase  of total resection rate by iMRI was statistically significant (p = 0.0007). Recurrent  tumour growth was seen in 5 (3%) patients during follow-up.\n        CONCLUSIONS:  Transsphenoidal surgery is the primary  treatment for most sellar lesions. The use of iMRI may lead to higher gross  total resection rates. In Switzerland  close cooperation between specialised centres is a very positive experience  both to support operative case loads and to optimise patient follow-up.<\/jats:p>","DOI":"10.4414\/smw.2012.13680","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T12:44:45Z","timestamp":1349441085000},"page":"w13680","source":"Crossref","is-referenced-by-count":13,"title":["Pituitary surgery: experience from a large  network\u00a0in Central Switzerland"],"prefix":"10.57187","volume":"142","author":[{"given":"Sven","family":"Berkmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl F","family":"Kothbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Henzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Landolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2012,9,23]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1593\/2070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1593\/2071","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1593\/2070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:10:04Z","timestamp":1755231004000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,23]]},"references-count":0,"journal-issue":{"issue":"3940","published-online":{"date-parts":[[2012,9,24]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13680","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,23]]}}}