{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:00:50Z","timestamp":1763017250702,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3940","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>New oral  anticoagulants used as single target inhibitors of coagulation enzymes have  been developed and tested in extensive trial programmes. Results of most of  these trials showed non-inferior and\/or superior efficacy and safety compared  to standard treatment with LMWH or VKA. These results led to registration of  these agents for the prophylaxis or treatment of thrombosis, as well as stroke  prophylaxis in atrial fibrillation. In addition to good efficacy and safety  these agents are more convenient in their use and promise advantages in quality  of life. Caution is needed, though, since drug-interactions, interferences with  coagulation tests and risk of accumulation in case of renal failure should  always be taken into consideration when planning a treatment. In the present  current-opinion review these advantages and disadvantages are discussed and  expressed options are analysed.<\/jats:p>","DOI":"10.4414\/smw.2012.13684","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T12:44:45Z","timestamp":1349441085000},"page":"w13684","source":"Crossref","is-referenced-by-count":5,"title":["Anticoagulant treatment: the end of the old agents?"],"prefix":"10.57187","volume":"142","author":[{"given":"Lukas","family":"Graf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios A","family":"Tsakiris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,9,23]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1592\/2068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1592\/2069","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1592\/2068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:09:52Z","timestamp":1755230992000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,23]]},"references-count":0,"journal-issue":{"issue":"3940","published-online":{"date-parts":[[2012,9,24]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2012.13684","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2012,9,23]]}}}