{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:17:06Z","timestamp":1774927026926,"version":"3.50.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0102","license":[{"start":{"date-parts":[[2012,12,30]],"date-time":"2012-12-30T00:00:00Z","timestamp":1356825600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:The pathogenesis of elevated blood  pressure and other cardiovascular risk factors in the population and their  progression over time is still incompletely understood, especially in young and healthy adults.\n        METHODS:The genetic and phenotypic  determinants of blood pressure and other cardiovascular risk factors (GAPP)  study is a population-based prospective cohort study involving a representative  sample of healthy adults aged 25\u201341 years in the Principality of Liechtenstein.  Exclusion criteria are any cardiovascular disease, diabetes, obstructive sleep  apnoea syndrome, daily intake of nonsteroidal anti-inflammatory drugs and a  body mass index &gt;35 kg\/m\u00b2. Examinations include detailed assessment of  personal, medical, lifestyle and nutritional factors, standardised assessment  of weight, height and waist circumference, blood pressure measurement (clinic  and 24-hour ambulatory monitoring), electrocardiography (12-lead and 24-hour  Holter monitoring), bioimpedance analysis, blood, urinary and genetic sampling,  spirometry and sleep pulse oximetry with nasal flow measurement. Baseline  examination is still ongoing. Follow-up examinations are scheduled every 3\u20135  years.\n        RESULTS:Since June 2010, 1,333 participants  have been enrolled. Mean age of the participants was 36.7 \u00b1 4.9 years and 47.5%  of all participants were male. Mean body mass index was 26.1 \u00b1 3.1 kg\/m2 in men and 23.5 \u00b1 3.9 kg\/m2 in women. The prevalence of hypertension  and prediabetes was 24.7% and 32.1% in men and 6% and 23% in women  respectively. Mean LDL levels were 3.34 \u00b1 0.9 mmol\/l in men and 2.75 \u00b1 0.7  mmol\/l in women. Median hsCRP was 0.9 (0.5; 1.8) mg\/l with no gender  differences.\n        CONCLUSION:GAPP affords an excellent opportunity to assess genetic and phenotypic  predictors of cardiovascular risk factors and their progression over time in young  and healthy adults from the general population.<\/jats:p>","DOI":"10.4414\/smw.2013.13728","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T01:11:02Z","timestamp":1359076262000},"page":"w13728","source":"Crossref","is-referenced-by-count":11,"title":["Genetic  and phenotypic determinants of blood pressure and other cardiovascular risk  factors"],"prefix":"10.57187","volume":"143","author":[{"given":"David","family":"Conen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Sch\u00f6n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Aeschbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Par\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Frehner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Risch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Risch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2012,12,30]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1803\/2489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1803\/2490","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1803\/2489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:09:50Z","timestamp":1755234590000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,30]]},"references-count":0,"journal-issue":{"issue":"0102","published-online":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13728","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,30]]}}}