{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:17:36Z","timestamp":1793762256283,"version":"4.6.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0910","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>PRINCIPLES: Interstitial pregnancy represents 2% of ectopic pregnancies, but it is a highly  morbid condition with a 2.5% of maternal mortality. Its diagnostic and  therapeutic management remains controversial. The aim of this review is to  describe the management of interstitial pregnancy in our institution between 2001  and 2011 and to define some general rules for the clinical practice.\n        METHODS: Single institution retrospective study.\n        RESULTS: Eleven women were treated for interstitial  pregnancy. The median age was 33 years and the median gestity was 4. Seven  patients had a history of gynaecological surgery and four interstitial  pregnancies followed in vitro fertilisation. The diagnosis was made at a median  gestational age of seven weeks with a median beta-HCG level of 5,838 U\/l. Six  of the eleven patients received an initial treatment with intracornual methotrexate,  three with intramuscular methotrexate and two with surgery. The median time to  beta-HCG resolution was 58 days. Three of  the eleven patients needed a second line treatment: two after intramuscular methotrexate  and one after intracornual methotrexate. Six patients had further pregnancies  and delivered by caesarean section.\n        CONCLUSIONS: A high prevalence of previous ectopic pregnancies, gynaecological  surgery and of pregnancies resulting from in vitro fertilisation was observed.  The earliness of the  diagnosis was the factor that allowed a conservative treatment in most cases.  Beta-HCG level follow up was fundamental in allowing a second line therapy but  beta-HCG can persist over a long period of time and this must be taken into  account due to its possible psychological impact. Intracornual  methotrexate seems to be more efficacious than intramuscular  methotrexate in our series.<\/jats:p>","DOI":"10.4414\/smw.2013.13736","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T06:29:02Z","timestamp":1366180142000},"page":"w13736","source":"Crossref","is-referenced-by-count":16,"title":["Interstitial pregnancies' diagnosis and management: an eleven cases series"],"prefix":"10.57187","volume":"143","author":[{"given":"Anna","family":"Surbone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cottier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Vial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katyuska","family":"Francini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hohlfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahin","family":"Achtari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,2,24]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1655\/2188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1655\/2189","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1655\/2188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:22:22Z","timestamp":1755231742000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,24]]},"references-count":0,"journal-issue":{"issue":"0910","published-online":{"date-parts":[[2013,2,25]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13736","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,24]]}}}