{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:22:47Z","timestamp":1770963767464,"version":"3.50.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0304","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Inflammation  is an important component of normal responses to infection and injury. However,  chronic activation of the immune system,  due to aberrant responses to  normal stimuli, can lead to the establishment of a persistent inflammatory state. Such  inflammatory conditions are often debilitating, and are associated with a  number of important co-morbidities including cardiovascular disease. Resting non-proliferative  tissues have distinctive metabolic activities and requirements, which differ  considerably from those in infiltrating immune cells, which are undergoing  proliferation and differentiation. Immune responses in tissues may therefore be  modulated by the relative abundance of substrates in the inflamed site. In turn  immune cell activity can feed back and affect metabolic behaviour of the  tissues, as most clearly demonstrated in cachexia \u2013 the loss of cellular mass  driven by tumour necrosis factor-alpha (TNF-\u03b1) a key mediator of the  inflammatory response. Here we discuss the potential for metabolomic analysis  to clarify the interactions between inflammation and metabolic changes  underlying many diseases. We suggest that an increased understanding of the  interaction between inflammation and cellular metabolism, energy substrate use,  tissue breakdown markers, the microbiome and drug metabolites, may provide novel  insight into the regulation of inflammatory diseases.<\/jats:p>","DOI":"10.4414\/smw.2013.13743","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T01:11:02Z","timestamp":1359076262000},"page":"w13743","source":"Crossref","is-referenced-by-count":28,"title":["Metabolomics \u2013 a novel window into inflammatory disease"],"prefix":"10.57187","volume":"143","author":[{"given":"Martin\u00a0A","family":"Fitzpatrick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2013,1,13]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1637\/2156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1637\/2157","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1637\/2156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:17:55Z","timestamp":1755231475000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,13]]},"references-count":0,"journal-issue":{"issue":"0304","published-online":{"date-parts":[[2013,1,14]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13743","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,13]]}}}