{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:52:33Z","timestamp":1783947153666,"version":"3.55.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"0304","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS  UNDER STUDY: To evaluate the diagnostic value of serum Cystatin C and urine  neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute  kidney injury in patients undergoing congenital heart surgery.\n        METHODS:  Serial samples of serum Cystatin C and urine NGAL were collected from 139  consecutive patients with congenital heart defects aged 3 days to 30 years  after admission to the intensive care unit, 2 and 6 hours after the end of  cardiopulmonary bypass. Biomarker levels were compared to perioperative data  retrospectively. Acute kidney injury was defined according to the paediatric-modified  RIFLE classification.\n        RESULTS: According  to the paediatric-modified RIFLE criteria 53% of patients developed evidence of  acute kidney injury. Serum Cystatin C concentrations were strongly correlated  with severity of acute kidney injury. Optimal sensitivity of 80% and  specificity of 66% for the prediction of acute kidney injury occurred at a  cut-off value of 0.995 mg\/l, 2 hours after the end of cardiopulmonary bypass. The  2 hour urine NGAL concentration was significantly correlated to the duration of  cardiopulmonary bypass, time of aortic cross clamping, and serum lactate  concentration. Moreover a significant correlation was found between urine NGAL  and both length of hospital stay and mechanical ventilation.\n        CONCLUSIONS:  In patients after congenital heart surgery, urine NGAL indicates the damaging  force of cardiopulmonary bypass and serum Cystatin C is a valuable predictive  biomarker for resulting acute kidney injury.<\/jats:p>","DOI":"10.4414\/smw.2013.13744","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T01:11:02Z","timestamp":1359076262000},"page":"w13744","source":"Crossref","is-referenced-by-count":12,"title":["Cystatin  C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney  injury after congenital heart surgery"],"prefix":"10.57187","volume":"143","author":[{"given":"Stefanie","family":"Seitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Rauh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gloeckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cesnjevar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas\u00a0Max","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,1,13]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1641\/2164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1641\/2165","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1641\/2164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:18:44Z","timestamp":1755231524000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,13]]},"references-count":0,"journal-issue":{"issue":"0304","published-online":{"date-parts":[[2013,1,14]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13744","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,13]]}}}