{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:02:29Z","timestamp":1789678949582,"version":"4.0.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"2728","license":[{"start":{"date-parts":[[2013,6,30]],"date-time":"2013-06-30T00:00:00Z","timestamp":1372550400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTION UNDER  STUDY: The frequency of severe adverse drug reactions (ADRs) from psychotropic  drugs was investigated in hospitalised psychiatric patients in relation to  their age. Specifically, the incidence of ADRs in patients up to 60 years was  compared to that of patients older than 60 years.\n        METHODS: Prescription  rates of psychotropic drugs and reports of severe ADRs were collected in psychiatric  hospitals in Switzerland between 2001 and 2010. The data stem from the drug  surveillance programme AMSP.\n        RESULTS: A  total of 699 patients exhibited severe ADRs: 517 out of 28,282 patients up to  60 years (1.8%); 182 out of 11,446 elderly patients (1.6%, ns). Logistic  regression analyses showed a significantly negative relationship between the  incidence of ADRs and patients\u2019 age in general and in particular for weight  gain, extrapyramidal motor system (EPMS) symptoms, increased liver enzymes and  galactorrhoea.  A significantly negative relationship  was observed for age and the dosages of olanzapine, quetiapine, risperidone,  valproic acid and lamotrigine. When comparing age groups, frequency of ADRs was  lower in general for antipsychotic drugs and anticonvulsants, in particular for  valproic acid in the elderly. Weight gain was found to be lower in the elderly  for antipsychotic drugs, in particular for olanzapine. For the group of  mood-stabilising anticonvulsants (carbamazepine, lamotrigine and valproic acid)  the elderly exhibited a lower incidence of reported allergic skin reactions.\n        CONCLUSION:  The results suggest that for psychiatric inpatients the incidence of common  severe ADRs (e.g., weight gain or EPMS symptoms) arising from psychotropic  medication decreases with the age of patients.<\/jats:p>","DOI":"10.4414\/smw.2013.13772","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13772","source":"Crossref","is-referenced-by-count":8,"title":["Age and  adverse drug reactions from psychopharmacological treatment"],"prefix":"10.57187","volume":"143","author":[{"given":"Waldemar","family":"Greil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"H\u00e4berle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Grohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,6,30]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1712\/2306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1712\/2307","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1712\/2306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:35:10Z","timestamp":1755232510000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,30]]},"references-count":0,"journal-issue":{"issue":"2728","published-online":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13772","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,30]]}}}