{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:48:23Z","timestamp":1791143303613,"version":"4.1.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1314","license":[{"start":{"date-parts":[[2013,3,24]],"date-time":"2013-03-24T00:00:00Z","timestamp":1364083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>STUDY\/PRINCIPLES: Antibiotic prophylaxis of Group B Streptococcus  (GBS) positive women during labour reduces the risk of early-onset neonatal  sepsis. Penicillin is the first choice, and clindamycin and erythromycin are  second choices for penicillin-allergic women. Resistance to these antibiotics  is rising. The aims of this study were to evaluate the rates of clindamycin and  erythromycin resistance among GBS-positive isolates cultures from pregnant  women in the University Hospital of Geneva and to evaluate the legitimacy of  new Centres for Disease Control and Prevention (CDC) recommendations for our  context.\n        METHODS: We  collected a vagino-rectal swab from pregnant women at 35\u201337 weeks gestation. We  recovered 124 GBS positive isolates. Identification was based on the  characteristic of the colony on the chromogenic agar, the streptococcal  agglutination test and confirmation by mass spectrometry. Antimicrobial  susceptibility was determined by disk diffusion, according to CLSI guidelines  2010.\n        RESULTS: The  rate of resistance to clindamycin was 28% and to erythromycin was 30%. Only 3  of the 38 erythromycin resistant strains (7.9%) were susceptible to  clindamycin, and only 3 out of the 35 clindamycin resistant GBS (8.6%) were  identified as \u201cinducible resistance\u201d. The rate of co-resistance to clindamycin  of erythromycin-resistant strains was 92%. Penicillin remained efficacious in  all cases.\n        CONCLUSION:  Rates of clindamycin and erythromycin resistance are also increasing in our  context. These antibiotics should not be used for GBS neonatal sepsis  prevention, without adequate antimicrobial susceptibility testing. In case of  penicillin allergy and lack of antibiogramm, cephalosporins or vancomycin  should be used as recommended in CDC guidelines.<\/jats:p>","DOI":"10.4414\/smw.2013.13778","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T06:29:02Z","timestamp":1366180142000},"page":"w13778","source":"Crossref","is-referenced-by-count":16,"title":["Antibiotic  resistance patterns among group B Streptococcus isolates: implications for  antibiotic prophylaxis for early-onset neonatal sepsis"],"prefix":"10.57187","volume":"143","author":[{"given":"Federica","family":"Capanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane\u00a0Paul","family":"Emonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdessalam","family":"Cherkaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier\u00a0Patrick","family":"Irion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Schrenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Martinez de Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,3,24]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1669\/2216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1669\/2217","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1669\/2216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:25:21Z","timestamp":1755231921000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,24]]},"references-count":0,"journal-issue":{"issue":"1314","published-online":{"date-parts":[[2013,3,25]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13778","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,24]]}}}