{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:12:34Z","timestamp":1777990354291,"version":"3.51.4"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"1516","license":[{"start":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T00:00:00Z","timestamp":1365292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND:  A small proportion of patients with influenza H1N1 rapidly develop acute respiratory  failure and are a problem for intensive care units (ICUs). Although certain clinical  risk factors have been identified, few measurable biochemical\/haematological  markers able to predict poor outcome have been reported. The aims of the  present report are to show which variables on and during admission are associated  with increased in-hospital mortality in patients admitted to the ICU with acute  respiratory failure due to H1N1 influenza.\n        METHODS: A  prospective observational study at two ICUs was carried out between August 2009  and March 2011. The study period covered two waves of pandemic influenza A H1N1  in Spain. Clinical and laboratory data on and during ICU admission were recorded  for the purpose of analysis.\n        RESULTS:Sixty patients with acute respiratory  failure due to H1N1 influenza were admitted during the period described above; 63.3%  (n = 38) were male and the mean age was 49.2 \u00b1 14 years. Regarding  comorbidities, 46.7% (n = 28) were smokers, 38% (n = 23) had hypertension, 30% (n  = 18) had a body mass index (BMI) &gt;30 kg\/m2, 30% (n = 18) had chronic  obstructive pulmonary disease and 26% (n = 16) had cardiac insufficiency; 16.6%  (n = 10) had bacterial co-infection, 70% (n = 42) required invasive mechanical  ventilation and 48.3% (n = 29) non-invasive mechanical ventilation. Mortality  was 20% (n = 12). Comparing survivors with non-survivors, univariate analysis  revealed significant differences in BMI, creatinine, haemoglobin, platelets,  arterial pH, pCO2, and the rate of bacterial co-infection. In the  multivariate analysis, only the presence of lower platelet count was  statistically significant (214 \u00b1 101 vs 113 \u00b1 82 \u00d7109\/L; p= 0.009). Patients with thrombocytopenia  showed a lower in-hospital survival rate (55%vs92.5%; Log Rank = 0.008).\n        CONCLUSIONS:Thrombocytopenia could be valuable  marker of in-hospital mortality in patients with respiratory failure due to  H1N1 influenza in the ICU scenario.<\/jats:p>","DOI":"10.4414\/smw.2013.13788","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13788","source":"Crossref","is-referenced-by-count":17,"title":["Thrombocytopenia  as a mortality risk factor in acute respiratory failure in H1N1 influenza"],"prefix":"10.57187","volume":"143","author":[{"given":"Juan Carlos","family":"Lopez-Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assumpta","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Ma\u00f1ez Mendiluce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Ball\u00fas Noguera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Berrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2013,4,7]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1671\/2220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1671\/2221","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1671\/2220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:25:48Z","timestamp":1755231948000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,7]]},"references-count":0,"journal-issue":{"issue":"1516","published-online":{"date-parts":[[2013,4,8]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13788","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,7]]}}}