{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:56:54Z","timestamp":1761155814261,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"4950","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>QUESTIONS UNDER  STUDY: Clinical trials do not necessarily reflect the results obtained in daily  clinical practice. By conducting a non-interventional, observational study with  biologics in rheumatoid arthritis (RA) patients in Switzerland, we aimed to generate  real-world data on reasons for treatment initiation and discontinuation,  physicians\u2019 expectations for treatment, co-medication, and various treatment  outcome parameters.\n        METHODS: Sixty-nine  patients with a confirmed diagnosis of RA were included in this  non-interventional observational study. Participating physicians used standardised  questionnaires to collect data on the use of biologics at three visits over one  year. Due to the small sample size of patients receiving biologics other than  abatacept, only patients treated with abatacept were considered for analysis.\n        RESULTS: The  population receiving intravenously administered abatacept consisted of 56  patients. Of these, 25% received abatacept as a first-line biologic therapy. The  retention rate over one year was high (75%) and similar to what has been  previously observed in randomised clinical trials. Overall, abatacept was found  to be effective in patients irrespective of their baseline disease activity or  levels in C-reactive protein and erythrocyte sedimentation rate. Moreover, the  use of glucocorticoids was found to be reduced under therapy. There was a  tendency for better treatment outcomes and physicians\u2019 satisfaction with abatacept  the earlier the drug was used in the sequence of biologic therapies.\n        CONCLUSIONS:  The present study suggests that abatacept is an effective and well tolerated  treatment in RA patients in routine clinical practice, irrespective of disease  parameter at baseline.<\/jats:p>","DOI":"10.4414\/smw.2013.13849","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13849","source":"Crossref","is-referenced-by-count":5,"title":["RAISE \u2013  Rheumatoid Arthritis Independent Swiss\u00a0Treatment Expectations and Outcome:  results\u00a0for\u00a0the abatacept subpopulation"],"prefix":"10.57187","volume":"143","author":[{"given":"Jean","family":"Dudler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Tuerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Handschin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2013,12,1]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1783\/2449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1783\/2450","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1783\/2449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:05:06Z","timestamp":1755234306000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":0,"journal-issue":{"issue":"4950","published-online":{"date-parts":[[2013,12,2]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13849","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}