{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:12:54Z","timestamp":1756462374829,"version":"3.44.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"3536","license":[{"start":{"date-parts":[[2013,8,25]],"date-time":"2013-08-25T00:00:00Z","timestamp":1377388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>OBJECTIVES:  Several  studies have reported prolonged QTc intervals in patients under methadone  maintenance treatment, including development of torsade-de-pointes arrhythmia  and death. It is still not clear why some patients develop critical QTc extensions  while others do not.\n        METHODS: ECG findings in a convenience sample of 210  methadone-maintained heroin-dependent patients, taking HCV-infection status and  methadone dosage into account simultaneously by means of a multiple linear  regression model with QTc-interval as the dependent variable.\n        RESULTS: Prolonged QTc-time is associated with hepatitis C  infections (p = 0.005) and higher  doses of racemic methadone (p = 0.012).\n        CONCLUSION: Infection with hepatitis C increases the likelihood of critical QTc prolongation in  patients in methadone maintenance treatment.<\/jats:p>","DOI":"10.4414\/smw.2013.13852","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13852","source":"Crossref","is-referenced-by-count":1,"title":["QTc  prolongation in methadone maintenance \u2013 the\u00a0role\u00a0of\u00a0HCV infection"],"prefix":"10.57187","volume":"143","author":[{"given":"Najibulah","family":"Gholami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Falcato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Stohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bruggmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2013,8,25]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1743\/2368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1743\/2369","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1743\/2368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T04:55:15Z","timestamp":1755233715000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,25]]},"references-count":0,"journal-issue":{"issue":"3536","published-online":{"date-parts":[[2013,8,26]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13852","relation":{},"ISSN":["1424-3997"],"issn-type":[{"type":"electronic","value":"1424-3997"}],"subject":[],"published":{"date-parts":[[2013,8,25]]}}}