{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:13:46Z","timestamp":1769840026258,"version":"3.49.0"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"4546","license":[{"start":{"date-parts":[[2013,11,3]],"date-time":"2013-11-03T00:00:00Z","timestamp":1383436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>Mantle  cell lymphoma (MCL) is a relatively rare lymphoma entity accounting for an  estimated 3%\u20136% of all non-Hodgkin\u2019s lymphoma cases. Characterised by both the incurability  of indolent lymphomas and the rapid growth of aggressive lymphomas, MCL has a median  overall survival of only 4\u20135 years. Although the disease often shows an  encouraging response to first-line treatment, its clinical course is usually  marked by recurrent relapses, resulting in a dismal long-term outcome. The  choice of therapy for managing the disease is a complex problem that still  requires evidence-based guidance. Owing to the rarity of MCL, the bulk of data  comes from phase II trials in small numbers of patients. Nevertheless,  therapeutic strategies for MCL have evolved in an effort to adapt treatment  according to the individual patient\u2019s risk profile, and the overall survival has  nearly doubled in the last 30 years. The use of effective immunochemotherapy  regimens in first-line therapy, advances in stem cell transplantation, and the development  of more active salvage therapy regimens have improved the outcome. This review  will summarise the key factors that drive clinical practice with respect to the  management of MCL.<\/jats:p>","DOI":"10.4414\/smw.2013.13868","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13868","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis  and treatment of mantle cell lymphoma"],"prefix":"10.57187","volume":"143","author":[{"given":"Felicitas","family":"Hitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bargetzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cogliatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lohri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Taverna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Renner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Mey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36756","published-online":{"date-parts":[[2013,11,3]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1773\/2428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1773\/2429","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1773\/2428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:01:30Z","timestamp":1755234090000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,3]]},"references-count":0,"journal-issue":{"issue":"4546","published-online":{"date-parts":[[2013,11,4]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13868","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,3]]}}}