{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:03:28Z","timestamp":1781093008112,"version":"3.54.1"},"reference-count":0,"publisher":"SMW Supporting Association","issue":"4546","license":[{"start":{"date-parts":[[2013,11,3]],"date-time":"2013-11-03T00:00:00Z","timestamp":1383436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Swiss Med Wkly"],"abstract":"<jats:p>BACKGROUND: Male breast cancer  patients have a higher risk of developing a second primary cancer, but whether  this risk differs according to the family history of breast or ovarian cancers remains to  be elucidated. We aimed to determine the effect of a positive  family history among men diagnosed with breast cancer on tumour  characteristics, treatment, second cancer occurrence and overall survival.\n        METHODS: We included 46 patients with known information on the  family history of breast or ovarian cancer recorded at the Geneva Cancer  Registry between 1970 and 2009. We compared patients with and without a family  history with chi-square of heterogeneity, risk of  second cancer with standardised incidence ratios (SIRs), and overall survival by  Kaplan-Meier methods.\n        RESULTS: Approximately 20% of men with breast cancer had a positive  family history. No differences were observed between men with and without familial  risk except that patients with increased risk were more likely to receive  radiotherapy and hormone therapy when compared with patients without familial  risk. This more complete therapy is likely to be explained by the  heightened awareness of cancer treatment among breast cancer patients with  affected family members. Six men developed a second  cancer. SIRs for second cancer were not significantly increased among patients  with or without familial risk (1.93, 95% confidence interval [CI] 0.23\u20136.97 and  1.04, 95% CI 0.28\u20132.66, respectively). Overall survival was not significantly  different between the two groups.\n        CONCLUSIONS: Prognosis was similar among patients with or  without familial risk. Our results are however based on small numbers and larger registry-based cohorts of males with precise  data on familial risk are still warranted.<\/jats:p>","DOI":"10.4414\/smw.2013.13879","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T10:27:23Z","timestamp":1404383243000},"page":"w13879","source":"Crossref","is-referenced-by-count":3,"title":["Impact of family history of breast cancer on tumour  characteristics, treatment, risk of second cancer and survival among men with  breast cancer"],"prefix":"10.57187","volume":"143","author":[{"given":"Christine","family":"Bouchardy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Rapiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Fioretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyma","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chappuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Vlastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Benhamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36756","published-online":{"date-parts":[[2013,11,3]]},"container-title":["Swiss Medical Weekly"],"original-title":[],"link":[{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1776\/2434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1776\/2435","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/download\/1776\/2434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:02:32Z","timestamp":1755234152000},"score":1,"resource":{"primary":{"URL":"https:\/\/smw.ch\/index.php\/smw\/article\/view\/1776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,3]]},"references-count":0,"journal-issue":{"issue":"4546","published-online":{"date-parts":[[2013,11,4]]}},"URL":"https:\/\/doi.org\/10.4414\/smw.2013.13879","relation":{},"ISSN":["1424-3997"],"issn-type":[{"value":"1424-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,3]]}}}